Why All the Fuss about Oxidative Phosphorylation (OXPHOS)?
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
10 12 2020
10 12 2020
Historique:
pubmed:
27
10
2020
medline:
2
2
2021
entrez:
26
10
2020
Statut:
ppublish
Résumé
Certain subtypes of cancer cells require oxidative phosphorylation (OXPHOS) to survive. Increased OXPHOS dependency is frequently a hallmark of cancer stem cells and cells resistant to chemotherapy and targeted therapies. Suppressing the OXPHOS function might also influence the tumor microenvironment by alleviating hypoxia and improving the antitumor immune response. Thus, targeting OXPHOS is a promising strategy to treat various cancers. A growing arsenal of therapeutic agents is under development to inhibit this biological process. This Perspective provides an overview of the structure and function of OXPHOS complexes, their biological functions in cancer, relevant research tools and models, as well as the limitations of OXPHOS as drug targets. We also focus on the current development status of OXPHOS inhibitors and potential therapeutic strategies to strengthen their clinical applications.
Identifiants
pubmed: 33103432
doi: 10.1021/acs.jmedchem.0c01013
pmc: PMC9298160
mid: NIHMS1810330
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
14276-14307Subventions
Organisme : NCI NIH HHS
ID : R01 CA188252
Pays : United States
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