Daptomycin-based aminoglycoside-sparing therapy for streptococcal endocarditis: a retrospective multicenter study.
Adult
Aged
Aminoglycosides
/ adverse effects
Anti-Bacterial Agents
/ administration & dosage
Daptomycin
/ administration & dosage
Drug Therapy, Combination
Endocarditis, Bacterial
/ drug therapy
Female
Gentamicins
/ administration & dosage
Humans
Italy
Male
Middle Aged
Renal Insufficiency
/ chemically induced
Retrospective Studies
Streptococcal Infections
/ drug therapy
beta-Lactams
/ administration & dosage
Acute kidney injury
Aminoglycoside-sparing therapy
Daptomycin
Streptococcal endocarditis
endocarditis
Journal
Journal of chemotherapy (Florence, Italy)
ISSN: 1973-9478
Titre abrégé: J Chemother
Pays: England
ID NLM: 8907348
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
pubmed:
27
10
2020
medline:
18
1
2022
entrez:
26
10
2020
Statut:
ppublish
Résumé
Streptococci still represent common etiologic agents of infective endocarditis (IE). Although renal failure is frequently reported as an aminoglycoside-associated adverse event, last international guidelines recommend a beta-lactam/gentamicin combination therapy. We retrospectively evaluated the use of daptomycin-based aminoglycoside-sparing combination therapy for the treatment of streptococcal IE in seven referral hospitals in Italy. Retrospective, multicenter, observational study. All patients with streptococcal IE admitted from 2016 to 2018 were enrolled. Mortality and incidence of acute kidney injury (AKI) were compared between Group A (standard of care, SoC) and Group B (daptomycin-based aminoglycoside-sparing combination therapy). Fifty-four patients were enrolled, 33 in Group A and 21 in Group B. Mortality was 2/33 (6%) in Group A and 0 in Group B (
Identifiants
pubmed: 33103614
doi: 10.1080/1120009X.2020.1838830
doi:
Substances chimiques
Aminoglycosides
0
Anti-Bacterial Agents
0
Gentamicins
0
beta-Lactams
0
Daptomycin
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Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM