A phase II trial of bendamustine in combination with ofatumumab in patients with relapsed or refractory marginal zone B-cell lymphomas.
Aged
Antibodies, Monoclonal, Humanized
/ administration & dosage
Antineoplastic Combined Chemotherapy Protocols
/ administration & dosage
Bendamustine Hydrochloride
/ administration & dosage
Disease-Free Survival
Female
Humans
Lymphoma, B-Cell, Marginal Zone
/ drug therapy
Male
Middle Aged
Recurrence
Survival Rate
bendamustine
marginal zone lymphoma
ofatumumab
phase II trial
Journal
Hematological oncology
ISSN: 1099-1069
Titre abrégé: Hematol Oncol
Pays: England
ID NLM: 8307268
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
02
09
2020
revised:
12
10
2020
accepted:
19
10
2020
pubmed:
27
10
2020
medline:
3
3
2021
entrez:
26
10
2020
Statut:
ppublish
Résumé
Marginal zone lymphomas (MZLs) are indolent yet incurable lymphomas with frequent relapses following therapy. For patients with relapsed/refractory disease, no standard therapies exist. Here we report results of an exploratory phase II study aimed at assessing the efficacy and safety of the alkylator agent bendamustine in combination with the second-generation anti-CD20 monoclonal antibody, ofatumumab, in patients with relapsed or refractory MZL. Patients with MZL and previously treated with at least one line of systemic therapy were eligible. Treatment consisted in bendamustine (90 mg/m
Substances chimiques
Antibodies, Monoclonal, Humanized
0
Bendamustine Hydrochloride
981Y8SX18M
ofatumumab
M95KG522R0
Types de publication
Clinical Trial, Phase II
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
60-65Subventions
Organisme : Mundipharma Medical Company and Novartis Farma S.p.A provided the two drugs free of charge
Organisme : Novartis Farma S.p.A provided also partial financial support for the study.
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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