Custom-made trays for targeted treatment of oral vesiculobullous diseases: A proposed protocol.
corticosteroids
oral
silicone trays
treatment
vesiculobullous
Journal
Dermatologic therapy
ISSN: 1529-8019
Titre abrégé: Dermatol Ther
Pays: United States
ID NLM: 9700070
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
10
09
2020
revised:
08
10
2020
accepted:
18
10
2020
pubmed:
27
10
2020
medline:
9
3
2021
entrez:
26
10
2020
Statut:
ppublish
Résumé
Topical and intralesional corticosteroids (CS) are effective treatments for oral manifestations of autoimmune vesiculobullous diseases (VBD); however, may cause unnecessary absorption in the adjacent healthy mucosal surfaces, local infections, atrophy, and injection pain. To propose a protocol using a unique modality for targeted administration of CS for the treatment of local manifestations of oral VBD. The medical records of nine patients with systemic CS-resistant VBD oral lesions, were reviewed following 3 weeks of treatment and 3 months of tapering using a custom-made tray designed for precise application of topical CS targeted to the involved mucosa. Following treatment, lesions have healed in 8/9 patients. Involvement of surrounding mucosa was minimal, and no systemic adverse effects were recorded. The proposed protocol using custom-made trays for targeted CS treatment could be an effective alternative treatment for oral VBD.
Substances chimiques
Adrenal Cortex Hormones
0
Glucocorticoids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14446Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Baum S, Sakka N, Artsi O, Trau H, Barzilai A. Diagnosis and classification of autoimmune blistering diseases. Autoimmun Rev. 2014;13(4-5):482-489. https://doi.org/10.1016/j.autrev.2014.01.047.
Fleming TE, Korman NJ. Cicatricial pemphigoid. J Am Acad Dermatol. 2000;43(4):571-591; quiz 591-4. https://doi.org/10.1067/mjd.2000.107248.
Kiran MS, Vidya S, Aswal GS, Kumar V, V. R. Systematic topical steroids in the management of oral mucosal lesions. J Pharm Bioallied Sci. 2017;9(suppl 1):S1-S3. https://doi.org/10.4103/jpbs.JPBS_91_17.
Lozada-Nur F, Miranda C, Maliksi R. Double-blind clinical trial of 0.05% clobetasol propionate (corrected from proprionate) ointment in orabase and 0.05% fluocinonide ointment in orabase in the treatment of patients with oral vesiculoerosive diseases. Oral Surg Oral Med Oral Pathol. 1994;77(6):598-604. https://doi.org/10.1016/0030-4220(94)90318-2.
Scully C, Beyli M, Ferreiro MC, et al. Update on oral lichen planus: etiopathogenesis and management. Crit Rev Oral Biol Med. 1998;9(1):86-122. https://doi.org/10.1177/10454411980090010501.
Joly P, Roujeau JC, Benichou J, et al. A comparison of oral and topical corticosteroids in patients with bullous pemphigoid. N Engl J Med. 2002;346(5):321-327. https://doi.org/10.1056/NEJMoa011592.
Gonzalez-Moles MA, Scully C. Vesiculo-erosive oral mucosal disease-management with topical corticosteroids: (1) fundamental principles and specific agents available. J Dent Res. 2005;84(4):294-301. https://doi.org/10.1177/154405910508400401.
Kassem R, Yarom N, Scope A, Babaev M, Trau H, Pavlotzky F. Treatment of erosive oral lichen planus with local ultraviolet B phototherapy. J Am Acad Dermatol. 2012;66(5):761-766. https://doi.org/10.1016/j.jaad.2011.04.017.
Carbone M, Conrotto D, Carrozzo M, Broccoletti R, Gandolfo S, Scully C. Topical corticosteroids in association with miconazole and chlorhexidine in the long-term management of atrophic-erosive oral lichen planus: a placebo-controlled and comparative study between clobetasol and fluocinonide. Oral Dis. 1999;5(1):44-49. https://doi.org/10.1111/j.1601-0825.1999.tb00063.x.
Gelfand JM, Werth VP. Treatment of bullous pemphigoid with topical corticosteroids: review of a randomized controlled trial. Arch Dermatol. 2002;138(9):1236-1237. https://doi.org/10.1001/archderm.138.9.1236.
Kassem R, Peretz A, Porat Ben Amy D. Topical paromomycin for treating solitary mucosal leishmaniasis. Int J Dermatol. 2018;57(6):721-723. https://doi.org/10.1111/ijd.13930.