Mitochondrial pyruvate carriers are required for myocardial stress adaptation.

Adaptation, Physiological / genetics Animals Anion Transport Proteins / genetics Cardiomegaly / diagnostic imaging Cardiomyopathy, Dilated / genetics Constriction, Pathologic Cytosol / metabolism Diet, High-Fat Diet, Ketogenic Echocardiography In Vitro Techniques Mice Mice, Knockout Mitochondria, Heart / metabolism Mitochondrial Membrane Transport Proteins / genetics Myocardium / metabolism Myocytes, Cardiac / metabolism Pyruvic Acid / metabolism Stress, Physiological / genetics

Journal

Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592

Informations de publication

Date de publication:
11 2020
Historique:
received: 17 02 2020
accepted: 03 09 2020
pubmed: 28 10 2020
medline: 1 1 2021
entrez: 27 10 2020
Statut: ppublish

Résumé

In addition to fatty acids, glucose and lactate are important myocardial substrates under physiologic and stress conditions. They are metabolized to pyruvate, which enters mitochondria via the mitochondrial pyruvate carrier (MPC) for citric acid cycle metabolism. In the present study, we show that MPC-mediated mitochondrial pyruvate utilization is essential for the partitioning of glucose-derived cytosolic metabolic intermediates, which modulate myocardial stress adaptation. Mice with cardiomyocyte-restricted deletion of subunit 1 of MPC (cMPC1

Identifiants

DOI: 10.1038/s42255-020-00288-1 PMID: 33106689 PMC: PMC8015649
pubmed: 33106689
doi: 10.1038/s42255-020-00288-1
pii: 10.1038/s42255-020-00288-1
pmc: PMC8015649
mid: NIHMS1626170
doi:

Substances chimiques

Anion Transport Proteins 0
MPC2 pyruvate carrier protein, mouse 0
Mitochondrial Membrane Transport Proteins 0
Pyruvic Acid 8558G7RUTR

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1248-1264

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK091538
Pays : United States
Organisme : NIH HHS
ID : S10 OD016232
Pays : United States
Organisme : NIAMS NIH HHS
ID : R00 AR059190
Pays : United States
Organisme : NIH HHS
ID : S10 OD019941
Pays : United States
Organisme : NIH HHS
ID : S10 OD018210
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132525
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK110858
Pays : United States
Organisme : NIDDK NIH HHS
ID : F32 DK101183
Pays : United States
Organisme : NIH HHS
ID : S10 OD021505
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104998
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007638
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL113057
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL049244
Pays : United States

Commentaires et corrections

Type : ErratumIn

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Auteurs

Yuan Zhang (Y)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
ORCID: 0000-0003-0067-2096

Paul V Taufalele (PV)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
ORCID: 0000-0002-8239-6533

Jesse D Cochran (JD)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
ORCID: 0000-0001-9705-5785

Isabelle Robillard-Frayne (I)

Department of Nutrition, Université de Montréal and Montreal Heart Institute, Montreal, Canada.

Jonas Maximilian Marx (JM)

Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, USA.
Friedrich-Schiller University of Jena, Jena, Germany.
ORCID: 0000-0002-7935-288X

Jamie Soto (J)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Mouse Metabolic Phenotyping Core, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Adam J Rauckhorst (AJ)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
ORCID: 0000-0002-4101-0075

Fariba Tayyari (F)

Metabolomics Core Facility, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
ORCID: 0000-0002-5837-9231

Alvin D Pewa (AD)

Metabolomics Core Facility, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Lawrence R Gray (LR)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Lynn M Teesch (LM)

Metabolomics Core Facility, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Patrycja Puchalska (P)

Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, USA.
Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

Trevor R Funari (TR)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
ORCID: 0000-0002-1465-2590

Rose McGlauflin (R)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Kathy Zimmerman (K)

Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

William J Kutschke (WJ)

Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
ORCID: 0000-0002-9358-795X

Thomas Cassier (T)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Shannon Hitchcock (S)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Kevin Lin (K)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Kevin M Kato (KM)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
ORCID: 0000-0002-8466-7149

Jennifer L Stueve (JL)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
ORCID: 0000-0001-5037-7517

Lauren Haff (L)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Robert M Weiss (RM)

Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
ORCID: 0000-0003-1307-2647

James E Cox (JE)

Department of Biochemistry, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Metabolomics Core Research Facility, School of Medicine, University of Utah, Salt Lake City, UT, USA.
ORCID: 0000-0002-5977-2350

Jared Rutter (J)

Department of Biochemistry, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Howard Hughes Medical Institute, School of Medicine, University of Utah, Salt Lake City, UT, USA.
ORCID: 0000-0002-2710-9765

Eric B Taylor (EB)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Metabolomics Core Facility, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Peter A Crawford (PA)

Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, USA.
Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

E Douglas Lewandowski (ED)

Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, USA.
Department of Internal Medicine and Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, USA.
ORCID: 0000-0002-8970-9491

Christine Des Rosiers (C)

Department of Nutrition, Université de Montréal and Montreal Heart Institute, Montreal, Canada.

E Dale Abel (ED)

Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. DRCAdmin@uiowa.edu.
Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. DRCAdmin@uiowa.edu.
Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. DRCAdmin@uiowa.edu.
ORCID: 0000-0001-5290-0738

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Classifications MeSH

questionsmedicales.fr › Phénomènes biologiques › Adaptation biologique › Adaptation physiologique › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Eucaryotes › Animaux › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Hypertrophie › Cardiomégalie › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Laminopathies › Cardiomyopathie dilatée › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Sténose pathologique › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Cytosol › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Régime pauvre en glucides › Régime cétogène › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic cardiovasculaire › Tests de la fonction cardiaque › Échocardiographie › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondries du muscle › Mitochondries du myocarde › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Mitochondrial pyruvate carriers are required...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Mitochondrial pyruvate carriers are required...
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questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Mitochondrial pyruvate carriers are required...