Xanthones from
Animals
Antirheumatic Agents
/ pharmacokinetics
Arthritis, Experimental
/ drug therapy
Chromatography, High Pressure Liquid
Chromatography, Liquid
HEK293 Cells
Herb-Drug Interactions
Humans
Male
Mass Spectrometry
Methotrexate
/ pharmacokinetics
Rats
Rats, Sprague-Dawley
Securidaca
/ chemistry
Xanthones
/ isolation & purification
Pharmacokinetics
drug transporter
drug-drug interaction
organic anion transporter 3 (OAT3)
rheumatoid arthritis
Journal
Expert opinion on drug metabolism & toxicology
ISSN: 1744-7607
Titre abrégé: Expert Opin Drug Metab Toxicol
Pays: England
ID NLM: 101228422
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
pubmed:
28
10
2020
medline:
16
4
2021
entrez:
27
10
2020
Statut:
ppublish
Résumé
This study was designed to characterize the interaction between Collagen-induced arthritis (CIA) was induced in rats, which were treated with MTX, a xanthone-rich fraction (XRF), or MTX+XRF by gavage for 30 days. Clinical efficacy was assessed based on arthritis scores, serological analysis, and histological examination. Protein expression was investigated by either immunohistochemical or immunoblotting methods. MTX concentrations were determined by HPLC or LC-MS methods. Obtained results were further validated by XRF antagonized the antirheumatic effects of MTX It is suggested that the combined use of
Sections du résumé
BACKGROUND
BACKGROUND
This study was designed to characterize the interaction between
METHODS
METHODS
Collagen-induced arthritis (CIA) was induced in rats, which were treated with MTX, a xanthone-rich fraction (XRF), or MTX+XRF by gavage for 30 days. Clinical efficacy was assessed based on arthritis scores, serological analysis, and histological examination. Protein expression was investigated by either immunohistochemical or immunoblotting methods. MTX concentrations were determined by HPLC or LC-MS methods. Obtained results were further validated by
RESULTS
RESULTS
XRF antagonized the antirheumatic effects of MTX
CONCLUSION
CONCLUSIONS
It is suggested that the combined use of
Identifiants
pubmed: 33107357
doi: 10.1080/17425255.2021.1843634
doi:
Substances chimiques
Antirheumatic Agents
0
Xanthones
0
Methotrexate
YL5FZ2Y5U1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM