T cell-derived exosomes induced macrophage inflammatory protein-1α/β drive the trafficking of CD8
Adult
Biomarkers
CD8-Positive T-Lymphocytes
/ immunology
Case-Control Studies
Cell Movement
/ immunology
Chemokine CCL3
/ genetics
Chemokine CCL4
/ genetics
Cytokines
/ genetics
Disease Susceptibility
Exosomes
/ metabolism
Female
Gene Expression
Humans
Lichen Planus, Oral
/ etiology
Male
Middle Aged
Severity of Illness Index
T cell
exosome
macrophage inflammatory protein-1α/β
migration
oral lichen planus
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
10
07
2020
revised:
22
09
2020
accepted:
06
10
2020
pubmed:
28
10
2020
medline:
13
5
2021
entrez:
27
10
2020
Statut:
ppublish
Résumé
Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory disease with uncertain aetiology. Exosomes are nanosized particles with biological capacities. Here, we aimed to study the effects of T cell-derived exosomes (T-exos) on the pathogenesis of OLP and its mechanism. T-exos were incubated with Jurkat cells for 48 hours, and 26 cytokines in the supernatant were measured by luminex assay. The expression of macrophage inflammatory protein (MIP)-1α/β was detected using immunohistochemistry and ELISA; that of CCR1/3/5 on peripheral T cells was determined by flow cytometry. Transwell assay was performed to investigate the chemotactic effect of MIP-1α/β, and cells in the lower chambers were examinated by flow cytometry. As a result, OLP T-exos elevated the production of MIP-1α/β, which were highly expressed in OLP tissues and plasma. CCR1/5 were markedly expressed on OLP peripheral T cells, and the majority of CCR1/5
Identifiants
pubmed: 33107682
doi: 10.1111/jcmm.16020
pmc: PMC7754044
doi:
Substances chimiques
Biomarkers
0
Chemokine CCL3
0
Chemokine CCL4
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14086-14098Informations de copyright
© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
Références
Annu Rev Cell Dev Biol. 2012;28:337-62
pubmed: 22831642
Clin Dermatol. 2010 Jan-Feb;28(1):100-8
pubmed: 20082959
J Biol Chem. 2012 Jul 20;287(30):25266-79
pubmed: 22584577
J Cell Mol Med. 2020 Dec;24(23):14086-14098
pubmed: 33107682
Nature. 2018 Aug;560(7718):382-386
pubmed: 30089911
Int J Dermatol. 2015 Sep;54(9):1005-10
pubmed: 26147778
Nat Rev Mol Cell Biol. 2018 Apr;19(4):213-228
pubmed: 29339798
Annu Rev Immunol. 2011;29:71-109
pubmed: 21166540
Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Sep;122(3):332-54
pubmed: 27401683
Cytokine Growth Factor Rev. 2002 Dec;13(6):455-81
pubmed: 12401480
J Dermatol. 2011 Apr;38(4):335-44
pubmed: 21544941
J Invest Dermatol. 2017 Nov;137(11):2396-2406
pubmed: 28760660
Cells. 2019 Feb 12;8(2):
pubmed: 30759880
PLoS One. 2012;7(11):e49723
pubmed: 23166755
J Oral Pathol Med. 2009 Aug;38(7):559-64
pubmed: 19453840
Oral Dis. 2018 Apr;24(3):377-383
pubmed: 28741807
J Immunol. 2002 Apr 1;168(7):3235-41
pubmed: 11907077
Dev Cell. 2011 Oct 18;21(4):708-21
pubmed: 21962903
J Clin Immunol. 2012 Aug;32(4):794-801
pubmed: 22430646
J Oral Pathol Med. 2016 Jul;45(6):385-93
pubmed: 26693958
J Oral Pathol Med. 2015 Jan;44(1):1-14
pubmed: 24329772
J Med Genet. 2019 Jan;56(1):29-31
pubmed: 29997128
Mediators Inflamm. 2014;2014:701094
pubmed: 25114378
Sci Rep. 2017 Oct 17;7(1):13365
pubmed: 29042682
Nature. 2006 Apr 13;440(7086):890-5
pubmed: 16612374
Acta Neurobiol Exp (Wars). 2016;76(4):304-317
pubmed: 28094821
Mol Immunol. 2009 Sep;46(15):3076-85
pubmed: 19576636
J Eur Acad Dermatol Venereol. 2018 Jul;32(7):e264-e265
pubmed: 29314294
Cell Physiol Biochem. 2018;46(3):953-964
pubmed: 29669317
J Biol Chem. 2013 Apr 26;288(17):11649-61
pubmed: 23463506
Am J Pathol. 2003 Jul;163(1):261-8
pubmed: 12819030
Nat Rev Rheumatol. 2016 Jan;12(1):37-48
pubmed: 26633290
J Oral Pathol Med. 2012 Jul;41(6):484-9
pubmed: 22404248
Hum Pathol. 2018 Apr;74:43-53
pubmed: 29288692
Cell Metab. 2019 Feb 5;29(2):348-361.e6
pubmed: 30318337
Front Cell Dev Biol. 2016 Aug 17;4:84
pubmed: 27583248
Annu Rev Cell Dev Biol. 2014;30:255-89
pubmed: 25288114
J Oral Pathol Med. 2019 Feb;48(2):143-150
pubmed: 30447107
J Oral Pathol Med. 2010 Nov;39(10):729-34
pubmed: 20923445