Naringin Alleviates Atherosclerosis in ApoE
Animals
Apolipoproteins E
/ deficiency
Atherosclerosis
/ drug therapy
Cholesterol
/ metabolism
Cholesterol 7-alpha-Hydroxylase
/ genetics
Female
Fibroblast Growth Factors
/ genetics
Flavanones
/ administration & dosage
Gastrointestinal Microbiome
/ drug effects
Humans
Liver
/ drug effects
Mice
Mice, Knockout
Proprotein Convertase 9
/ genetics
atherosclerosis
bile acid
cholesterol metabolism
gut microbiota
naringin
Journal
Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755
Informations de publication
Date de publication:
11 Nov 2020
11 Nov 2020
Historique:
pubmed:
28
10
2020
medline:
19
3
2021
entrez:
27
10
2020
Statut:
ppublish
Résumé
Naringin, a major flavonoid in citrus, has potential for preventing atherosclerosis. The presence in the colon of a large amount of naringin after oral intake might affect the gut microbiota. We investigated the role of gut microbiota remodeling in the alleviation of atherosclerosis by naringin. Naringin significantly alleviated atherosclerosis and lowered the serum and liver cholesterol levels by 24.04 and 28.37% in ApoE
Identifiants
pubmed: 33107729
doi: 10.1021/acs.jafc.0c05800
doi:
Substances chimiques
Apolipoproteins E
0
Flavanones
0
fibroblast growth factor 15, mouse
0
Fibroblast Growth Factors
62031-54-3
Cholesterol
97C5T2UQ7J
Cholesterol 7-alpha-Hydroxylase
EC 1.14.14.23
Cyp7a1 protein, mouse
EC 1.14.14.23
Proprotein Convertase 9
EC 3.4.21.-
naringin
N7TD9J649B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM