Acute reversible SERCA blockade facilitates or blocks exocytosis, respectively in mouse or bovine chromaffin cells.
Acetylcholine
/ pharmacology
Animals
Calcium
/ metabolism
Calcium Signaling
/ drug effects
Catecholamines
/ metabolism
Cattle
Cells, Cultured
Chromaffin Cells
/ drug effects
Endoplasmic Reticulum
/ drug effects
Enzyme Inhibitors
/ pharmacology
Exocytosis
/ drug effects
Indoles
/ pharmacology
Male
Mice, Inbred C57BL
Sarcoplasmic Reticulum Calcium-Transporting ATPases
/ antagonists & inhibitors
Species Specificity
Thapsigargin
/ pharmacology
Time Factors
Bovine adrenal chromaffin cells
CICR
Calcium signaling
Cyclopiazonic acid
Exocytosis
Mouse adrenal chromaffin cells
SERCA
Journal
Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
09
09
2020
accepted:
20
10
2020
revised:
03
10
2020
pubmed:
28
10
2020
medline:
15
12
2021
entrez:
27
10
2020
Statut:
ppublish
Résumé
Pre-blockade of the sarco-endoplasmic reticulum (ER) calcium ATPase (SERCA) with irreversible thapsigargin depresses exocytosis in adrenal bovine chromaffin cells (BCCs). Distinct expression of voltage-dependent Ca
Identifiants
pubmed: 33108514
doi: 10.1007/s00424-020-02483-1
pii: 10.1007/s00424-020-02483-1
doi:
Substances chimiques
Catecholamines
0
Enzyme Inhibitors
0
Indoles
0
Thapsigargin
67526-95-8
Sarcoplasmic Reticulum Calcium-Transporting ATPases
EC 3.6.3.8
Acetylcholine
N9YNS0M02X
Calcium
SY7Q814VUP
cyclopiazonic acid
X9TLY4580Z
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
273-286Commentaires et corrections
Type : CommentIn
Références
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