Time cells in the human hippocampus and entorhinal cortex support episodic memory.
human electrophysiology
medial temporal lobe
theta precession
time cells
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
10 11 2020
10 11 2020
Historique:
pubmed:
29
10
2020
medline:
5
1
2021
entrez:
28
10
2020
Statut:
ppublish
Résumé
The organization of temporal information is critical for the encoding and retrieval of episodic memories. In the rodent hippocampus and entorhinal cortex, evidence accumulated over the last decade suggests that populations of "time cells" in the hippocampus encode temporal information. We identify time cells in humans using intracranial microelectrode recordings obtained from 27 human epilepsy patients who performed an episodic memory task. We show that time cell activity predicts the temporal organization of retrieved memory items. We also uncover evidence of ramping cell activity in humans, which represents a complementary type of temporal information. These findings establish a cellular mechanism for the representation of temporal information in the human brain needed to form episodic memories.
Identifiants
pubmed: 33109718
pii: 2013250117
doi: 10.1073/pnas.2013250117
pmc: PMC7668099
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
28463-28474Subventions
Organisme : NIMH NIH HHS
ID : R01 MH055687
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH104606
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107357
Pays : United States
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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