Recurrent HNSCC Harbor an Immunosuppressive Tumor Immune Microenvironment Suggesting Successful Tumor Immune Evasion.
Aged
CD8-Positive T-Lymphocytes
/ immunology
Carcinoma, Squamous Cell
/ immunology
Cell Line, Tumor
Cell Survival
/ genetics
Cohort Studies
Female
Forkhead Transcription Factors
/ immunology
Gene Expression Regulation, Neoplastic
/ immunology
Head and Neck Neoplasms
/ immunology
Humans
Lymphocytes, Tumor-Infiltrating
/ immunology
Male
Middle Aged
Neoplasm Recurrence, Local
Prognosis
Tumor Escape
/ genetics
Tumor Microenvironment
/ genetics
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 01 2021
15 01 2021
Historique:
received:
12
02
2020
revised:
24
07
2020
accepted:
23
10
2020
pubmed:
29
10
2020
medline:
11
1
2022
entrez:
28
10
2020
Statut:
ppublish
Résumé
Recurrent tumors (RT) of head and neck squamous cell carcinoma (HNSCC) occur in up to 60%, with poor therapeutic response and detrimental prognosis. We hypothesized that HNSCC RTs successfully evade antitumor immune response and aimed to reveal tumor immune microenvironment (TIME) changes of primary tumors (PT) and corresponding RTs. Tumor-infiltrating leukocytes (TIL) of 300 PTs and 108 RTs from two large independent and clinically well-characterized HNSCC cohorts [discovery cohort (DC), validation cohort (VD)] were compared by IHC. mRNA expression analysis of 730 immune-related genes was performed for 18 PTs and RTs after adjuvant chemoradiotherapy (CRT). The effect of chemotherapy and radiation resistance was assessed with an TIME analysis revealed overall decrease of TILs with significant loss of CD8 HNSCC RTs have an immunosuppressive TIME, which is particularly apparent after adjuvant CRT and might substantially contribute to poor therapeutic response and prognosis.
Identifiants
pubmed: 33109740
pii: 1078-0432.CCR-20-0197
doi: 10.1158/1078-0432.CCR-20-0197
doi:
Substances chimiques
FOXP3 protein, human
0
Forkhead Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
632-644Informations de copyright
©2020 American Association for Cancer Research.
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