Evolution of hyphenated techniques for mineral oil analysis in food.
aromatic hydrocarbons
comprehensive two-dimensional chromatography
food
liquid-gas chromatography
mineral oil
saturated hydrocarbons
Journal
Journal of separation science
ISSN: 1615-9314
Titre abrégé: J Sep Sci
Pays: Germany
ID NLM: 101088554
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
19
08
2020
revised:
04
10
2020
accepted:
26
10
2020
pubmed:
29
10
2020
medline:
21
9
2021
entrez:
28
10
2020
Statut:
ppublish
Résumé
The occurrence of mineral oil in food is known since the early 1990s, and it was discovered by chance in one of the first applications using the hyphenated LC-GC system. Since then, the relationship between hyphenated techniques and mineral oil analysis has been tightly interrelated and successful. This review aims to show and explain how this mutual interaction has driven the development of the hyphenated techniques on one side and has supported the increase of knowledge on the other, supporting the complex task of mineral oil determination in food. The paper presents the background of the mineral oil problem in food (a brief history of its finding, toxicology, and occurrence), moving then toward the analytical determination. The development of different hyphenated techniques in relation to mineral oil determination is discussed, focusing mainly on 2D techniques, such as LC-GC. The necessity of additional dimensions, such as LC-LC-GC and comprehensive approaches, such as GC × GC and LC × GC, is also discussed. Finally, the role of the hyphenation with MS is presented.
Identifiants
pubmed: 33111479
doi: 10.1002/jssc.202000901
doi:
Substances chimiques
Mineral Oil
8020-83-5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
464-482Informations de copyright
© 2020 Wiley-VCH GmbH.
Références
Grob K, Fröhlich D, Schilling B, Neukom HP, Nägeli P. Coupling of high-performance liquid chromatography with capillary gas chromatography. J Chromatogr. 1984;295:55-61.
Biedermann M, Grob K, Meier W. Partially concurrent eluent evaporation with an early vapor exit; detection of food irradiation through coupled LC-GC analysis of fat. J High Resolut Chromatogr. 1989;12:591-8.
Grob K, Artho A, Biedermann M, Egli J. Food Contamination by hydrocarbons from lubricating oils and release agents: Determination by coupled LC-GC. Food Addit Contam. 1991;8:437-46.
Purcaro G, Moret S, Conte L. Hyphenated liquid chromatography-gas chromatography technique: Recent evolution and applications. J Chromatogr A. 2012;1255:100-11.
Grob K. Could the Ukrainian sunflower oil contaminated with mineral oil wake up sleeping dogs? Eur J Lipid Sci Technol. 2008;110:979-81.
Biedermann M, Grob K. Is recycled newspaper suitable for food contact materials? Technical grade mineral oils from printing inks. Eur Food Res Technol. 2010;230:785-96.
Biedermann M, Fiselier K, Grob K Aromatic hydrocarbons of mineral oil origin in foods: Method for determining the total concentration and first result. J Agric Food Chem. 2009;57:8711-21.
European Food Safety Authorithy (EFSA). Scientific opinion on mineral oil hydrocarbons in food. EFSA J. 2012;10:2704.
Biedermann M, Grob K Memory effects with the on-column interface for on-line coupled high performance liquid chromatography-gas chromatography: The Y-interface. J Chromatogr A. 2009;1216:8652-8.
Biedermann M, Grob K Comprehensive two-dimensional GC after HPLC preseparation for the characterization of aromatic hydrocarbons of mineral oil origin in contaminated sunflower oil. J Sep Sci. 2009;32:3726-37.
Biedermann M, Munoz C, Grob K. Update of on-line coupled liquid chromatography-gas chromatography for the analysis of mineral oil hydrocarbons in foods and cosmetics. J Chromatogr A. 2017;1521:140-9.
Koch M, Becker E, Päch M, Kühn S, Kirchhoff E. Separation of the mineral oil aromatic hydrocarbons of three and more aromatic rings from those of one or two aromatic rings. J Sep Sci. 2020;43:1089-99.
Bratinova S, Hoekstra E, Emons H, Hutzler C, Kappenstein O, Biedermann M, McCombie G. The reliability of MOSH/MOAH data: A comment on a recently published article. J fur Verbraucherschutz und Leb. 2020;2-4.
European Commission. Commission Recommendation (EU) 2017/84 of 16 January 2017 on the monitoring of mineral oil hydrocarbons in food and in materials and articles intended to come into contact with food. Off J Eur Union. 2017;L12:95-96.
Bratinova S, Hoekstra E, Joint Research Center (JRC). Guidance on Sampling, Analysis and Data Reporting for the Monitoring of Mineral Oil Hydrocarbons in Food and Food Contact Materials. In the Frame of Commission Recommendation (EU) 2017/84. Publications Office of the European Union; 2019. https://ec.europa.eu/jrc/en/publication/guidance-sampling-analysis-and-data-reporting-monitoring-mineral-oil-hydrocarbons-food-and-food.
Purcaro G, Barp L, Moret S. Determination of hydrocarbon contamination in foods. A review. Anal Methods. 2016;8:5755-72.
Foodwatch. International test of various canned baby milk products for their content of mineral oil hydrocarbons (MOSH/MOAH). https://www.foodwatch.org/fileadmin/-INT/mineral_oil/documents/2019-10-24_Projectreport_babymilk_FINAL.pdf.
Arcella D, Baert K, Binaglia M Rapid risk assessment on the possible risk for public health due to the contamination of infant formula and follow-on formula by mineral oil aromatic hydrocarbons (MOAH). EFSA Support Publ. 2019;16. https://doi.org/10.2903/sp.efsa.2019.en-1741.
Scientific Committee of the Federal Agency for the Safety of the Food Chain. Advice 19-2017 Action Thresholds for Mineral Oil Hydrocarbons in Food; 2017.
Bund für Lebensmittelrecht und Lebensmittelkunde. Statement on the plan for a national “Mineral oil regulation.” 22nd regulation on the modification of the German Consumer Goods Ordinance; 2017.
European Commission. Regulation (EC) No. 1333/2008 of the European Parliament and of the Council of 16 December 2008 on food additives. Off J Eur Union. 2008;L354:16-33.
European Commission. Regulation (EU) No. 10/2011. Off J Eur Union. 2011;1-89.
European Commission. Regulation (EC) No. 889/2008 of 5 September 2008 laying down detailed rules for the implementation of Council Regulation (EC) No. 834/2007 on organic production and labelling of organic products with regard to organic production, labelling and con. Off J Eur Union. 2008;L250:1-84.
European Commission. Commission Implementing Regulation (EU) No. 540/2011 of 25 May 2011 implementing Regulation (EC) No. 1107/2009 of the European Parliament and of the Council as regards the list of approved active substances. Off J Eur Union. 2011;153:1-186.
Miller MJ, Lonardo EC, Greer RD, Bevan C, Edwards DA, Smith JH, Freeman JJ. Variable responses of species and strains to white mineral oils and paraffin waxes. Regul Toxicol Pharmacol. 1996;23:55-68.
Griffis LC, Twerdok LE, Francke-Carroll S, Biles RW, Schroeder RE, Bolte H, Faust H, Hall WC, Rojko J. Comparative 90-day dietary study of paraffin wax in Fischer-344 and Sprague-Dawley rats. Food Chem Toxicol. 2010;48:363-72.
Boogaard PJ, Goyak KO, Biles RW, van Stee LLP, Miller MS, Miller MJ. Comparative toxicokinetics of low-viscosity mineral oil in Fischer 344 rats, Sprague-Dawley rats, and humans-Implications for an acceptable daily intake (ADI). Regul Toxicol Pharmacol. 2012;63:69-77.
Cravedi J, Grob K, Nygaard UC, Alexander J. Bioaccumulation and toxicity of mineral oil hydrocarbons in rats-Specificity of different subclasses of a broad mixture relevant for human dietary exposures. EFSA Support Publ. 2017;14. https://doi.org/10.2903/sp.efsa.2017.en-1090.
Barp L, Biedermann M, Grob K, Blas-Y-Estrada F, Nygaard UC, Alexander J, Cravedi JP. Mineral oil saturated hydrocarbons (MOSH) in female Fischer 344 rats; accumulation of wax components; implications for risk assessment. Sci Total Environ. 2017;583:319-33.
Barp L, Biedermann M, Grob K, Blas-Y-Estrada F, Nygaard UC, Alexander J, Cravedi JP. Accumulation of mineral oil saturated hydrocarbons (MOSH) in female Fischer 344 rats: Comparison with human data and consequences for risk assessment. Sci Total Environ. 2017;575:1263-78.
Trimmer GW, Freeman JJ, Priston RA. U. J., Results of chronic dietary toxicity studies of high viscosity (P70H and P100H) white mineral oils in Fischer 344 rats. Toxicol Pathol. 2004;32:439-47.
Barp L, Kornauth C, Wuerger T, Rudas M, Biedermann M, Reiner A, Concin N, Grob K. Mineral oil in human tissues, Part I: Concentrations and molecular mass distributions. Food Chem Toxicol. 2014;72:312-21.
Biedermann M, Barp L, Kornauth C, Würger T, Rudas M, Reiner A, Concin N, Grob K. Mineral oil in human tissues, Part II: Characterization of the accumulated hydrocarbons by comprehensive two-dimensional gas chromatography. Sci Total Environ. 2015;506-507:644-55.
Adenuga D, Goyak K, Lewis RJ. Critical reviews in toxicology evaluating the MoA/human relevance framework for F-344 rat liver epithelioid granulomas with mineral oil hydrocarbons granulomas with mineral oil hydrocarbons. Crit Rev Toxicol. 2017;47:754-70.
van de Ven BM, Fragki S, te Biesebeek JD, Rietveld AG, Boon PE. Mineral oils in food; a review of toxicological data and an assessment of the dietary exposure in the Netherlands. RIVM Lett Rep 2017-0182. 2017. doi:10.21945/RIVM-2017-0182.
Carrillo J, Wiel A Van Der Danneels D, Kral O, Boogaard P The selective determination of potentially carcinogenic polycyclic aromatic compounds in lubricant base oils by the DMSO extraction method IP346 and its correlation to mouse skin painting carcinogenicity assays. Regul Toxicol Pharmacol. 2019;106:316-33.
Biedermann M, Grob K. On-line coupled high performance liquid chromatography-gas chromatography for the analysis of contamination by mineral oil. Part 1: Method of analysis. J Chromatogr A. 2012;1255:56-75.
Biedermann M, Grob K. On-line coupled high performance liquid chromatography-gas chromatography for the analysis of contamination by mineral oil. Part 2: Migration from paperboard into dry foods: Interpretation of chromatograms. J Chromatogr A. 2012;1255:76-99.
Weber S, Schrag K, Mildau G, Kuballa T, Walch SG, Lachenmeier DW. Analytical methods for the determination of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH)-A short review. Anal Chem Insights. 117739011877775, 2018;13. https://doi.org/10.1177/1177390118777757.
Moret S, Conchione C, Srbinovska A, Lucci P. Microwave-based technique for fast and reliable extraction of organic contaminants from food, with a special focus on hydrocarbon contaminants. Foods. 2019;8:503.
Moret S, Sander M, Purcaro G, Scolaro M, Barp L, Conte LS. Optimization of pressurized liquid extraction (PLE) for rapid determination of mineral oil saturated (MOSH) and aromatic hydrocarbons (MOAH) in cardboard and paper intended for food contact. Talanta. 2013;115:246-52.
Moret S, Scolaro M, Barp L, Purcaro G, Sander M, Conte LS. Optimisation of pressurised liquid extraction (PLE) for rapid and efficient extraction of superficial and total mineral oil contamination from dry foods. Food Chem. 2014;157:470-75.
Moret S, Scolaro M, Barp L, Purcaro G, Conte LS. Microwave assisted saponification (MAS) followed by on-line liquid chromatography (LC)-gas chromatography (GC) for high-throughput and high-sensitivity determination of mineral oil in different cereal-based foodstuffs. Food Chem. 2016;196:50-7.
Moret S, Barp L, Purcaro G, Conte LS. Rapid and sensitive solid phase extraction-large volume injection-gas chromatography for the analysis of mineral oil saturated and aromatic hydrocarbons in cardboard and dried foods. J Chromatogr A. 2012;1243:1-5.
Moret S, Barp L, Grob K, Conte LS. Optimised off-line SPE-GC-FID method for the determination of mineral oil saturated hydrocarbons (MOSH) in vegetable oils. Food Chem. 2011;129:1898-903.
Fiselier K, Grundböck F, Schön K, Kappenstein O, Pfaff K, Hutzler C, Luch A, Grob K. Development of a manual method for the determination of mineral oil in foods and paperboard. J Chromatogr A. 2013;1271:192-200.
Bundesinstitut für Risikobewertung (BfR). Determination of Hydrocarbons from Mineral Oil (MOSH & MOAH) or Plastics (POSH & PAO) in Packaging Materials and Dry Foodstuffs by Solid Phase Extraction and GC-FID; 2011. https://www.bfr.bund.de/cm/349/determination-of-hydrocarbons-from-mineral-oil-or-plastics.pdf.
Zurfluh M, Biedermann M, Grob K. Enrichment for reducing the detection limits for the analysis of mineral oil in fatty foods. J Consum Prot Food Saf. 2014;9:61-69.
Wrona M, Pezo D, Nerin C. Rapid analytical procedure for determination of mineral oils in edible oil by GC-FID. Food Chem. 2013;141:3993-9.
Fiselier K, Fiorini D, Grob K. Activated aluminum oxide selectively retaining long chain n-alkanes. Part I, description of the retention properties. Anal Chim Acta. 2009;634:96-101.
Fiselier K, Fiorini D, Grob K. Activated aluminum oxide selectively retaining long chain n-alkanes: Part II. Integration into an on-line high performance liquid chromatography-liquid chromatography-gas chromatography-flame ionization detection method to remove plant paraffins for the determination of mineral paraffins in foods and environmental samples. Anal Chim Acta. 2009;634:102-9.
Nestola M, Schmidt TC. Determination of mineral oil aromatic hydrocarbons in edible oils and fats by online liquid chromatography-gas chromatography-flame ionization detection-Evaluation of automated removal strategies for biogenic olefins. J Chromatogr A. 2017;1505:69-76.
Biedermann M, Munoz C, Grob K. Epoxidation for the analysis of the mineral oil aromatic hydrocarbons in food. An update. J Chromatogr A. 2020;1624:461236.
Purcaro G, Moret S, Conte L. Sample pre-fractionation of environmental and food samples using LC-GC multidimensional techniques. Trends Anal Chem. 2013;43:146-0.
Biedermann M, Grob K. Advanced Gas Chromatography in Food Analysis. London: Royal Society of Chemistry; 2020;283-326.
Grob K. On-Line Coupled LC-GC. Heidelberg, Germany: Hûthig; 1991.
Purcaro G. Hyphenation of Capillary Chromatography with Mass Spectrometry. Amsterdam: Elsevier; 2020;227-67.
Schmarr H, Mosandl A, Grob K. Coupled LC-GC: Evaporation rates for partially concurrent eluent evaporation using an early solvent vapor exit. J High Resolut Chromatogr. 1989;12:721-26.
Grob K. Efficiency through combining high-performance liquid chromatography and high resolution gas chromatography: Progress 1995-1999. J Chromatogr A. 2000;892:407-20.
Grob K, Lanfranchi M, Egli J, Artho A. Determination of food contamination by mineral oil from jute sacks using coupled LC-GC. J Assoc Off Anal Chem. 1991;74:506-12.
Grob K, Stoll J-M. Loop-type interface for concurrent solvent evaporation in analysis of raspberry ketone in a raspberry sauce as an example. J High Resolut Chromatogr Chromatogr Commun. 1986;9:518-23.
Grob K, Bronz M. On-line LC-GC transfer via a hot vaporizing chamber and vapor discharge by overflow; increased sensitivity for the determination of mineral oil in foods. J Microcolumn Sep. 1995;7:421-27.
Moret S, Grob K, Conte LS. On-line high-performance liquid chromatography-solvent evaporation-high-performance liquid chromatography-capillary gas chromatography-flame ionisation detection for the analysis of mineral oil polyaromatic hydrocarbons in fatty foods. J Chromatogr A. 1996;750:361-68.
Moret S, Grob K, Conte LS. Mineral oil polyaromatic hydrocarbons in foods, e.g. from jute bags, by on-line LC-solvent evaporation (SE)-LC-GC-FID. Z Leb Unters Forsch A. 1997;204:241-6.
Wagner C, Neukom HP, Galetti V, Grob K. Determination of mineral paraffins in feeds and foodstuffs by bromination and preseparation on aluminium oxide: Method and results of a ring test. Mitt Leb Hyg. 2001;92:231-49.
Grob K, Vass M, Biedermann M, Neukom H. Contamination of animal feed and food from animal origin with mineral oil hydrocarbons. Food Addit Contam. 2001;18:1-10.
Grob K, Schilling B. Retardation by phase soaking in capillary gas chromatography. J Chromatogr. 1983;260:265-75.
Grob K, Schilling B. Observation of a peak under the action of “phase soaking,” a gas chromatographic solvent effect, during passage through a capillary column. J Chromatogr A. 1983;259:37-48.
Neukom H, Grob K, Biedermann M, Noti A. Food contamination by C 20-C 50 mineral paraffins from the atmosphere. Atmos Environ. 2002;36:4839-47.
Moret S, Populin T, Conte LS, Grob K, Neukom H. Occurrence of C 15 -C 45 mineral paraffins in olives and olive oils. Food Addit Contam. 2003;20:417-26.
Tranchida PQ, Zoccali M, Purcaro G, Moret S, Conte L, Beccaria M, Dugo P, Mondello L. A rapid multidimensional liquid-gas chromatography method for the analysis of mineral oil saturated hydrocarbons in vegetable oils. J Chromatogr A. 2011;1218:7476-80.
Mondello L, Zoccali M, Purcaro G, Franchina FA, Sciarrone D, Moret S, Conte L, Tranchida PQ. Determination of saturated-hydrocarbon contamination in baby foods by using on-line liquid-gas chromatography and off-line liquid chromatography-comprehensive gas chromatography combined with mass spectrometry. J Chromatogr A. 2012;1259:221-6.
Zoccali M, Barp L, Beccaria M, Sciarrone D, Purcaro G, Mondello L. Improvement of mineral oil saturated and aromatic hydrocarbons determination in edible oil by liquid-liquid-gas chromatography with dual detection. J Sep Sci. 2016;39:623-31.
Purcaro G, Zoccali M, Tranchida PQ, Barp L, Moret S, Conte L. Comparison of two different multidimensional liquid-gas chromatography interfaces for determination of mineral oil saturated hydrocarbons in foodstuffs. Anal Bioanal Chem. 2013;405:1077-84.
Grob K, Kaelin I, Artho A. Coupled LC-GC: The capacity of silica gel (HP)LC columns for retaining fat. J High Resolut Chromatogr. 1991;14:373-6.
Biedermann-Brem S, Grob K. Removal of mineral oil migrated from paperboard packing during cooking of foods in boiling water. Eur Food Res Technol. 2011;232:1035-41.
Quigley WWC, Fraga CG, Synovec RE. Comprehensive LC x GC for enhanced headspace analysis. J Microcolumn Sep. 2000;12:160-6.
Koning S De Janssen H, Brinkman UAT. Group-type characterisation of mineral oil samples by two-dimensional comprehensive normal-phase liquid chromatography-gas chromatography with time-of-flight mass spectrometric detection. J Chromatogr A. 2004;1058:217-21.
Xu Y, Wang H, Zhao J, Guan Y. Analysis of alkylbenzene samples by comprehensive capillary liquid chromatography × capillary gas chromatography. J Chromatogr A. 2008;1181:95-102.
García-Cicourel AR, van de Velde B, Verduin J, Janssen HG. Comprehensive off-line silver phase liquid chromatography × gas chromatography with flame ionization and vacuum ultraviolet detection for the detailed characterization of mineral oil aromatic hydrocarbons. J Chromatogr A. 1607, 2019;460391. https://doi.org/10.1016/j.chroma.2019.460391.
García-Cicourel AR, Janssen H. Direct analysis of aromatic hydrocarbons in purified mineral oils for foods and cosmetics applications using gas chromatography with vacuum ultraviolet detection. J Chromatogr A. 2019;1590:113-20.
Fiselier K, Grob K. Determination of mineral oil paraffins in foods by on-line HPLC-GC-FID: Lowered detection limit; contamination of sunflower seeds and oils. Eur Food Res Technol. 2009;229:679-88.
Grundböck F, Fiselier K, Schmid F, Grob K. Mineral oil in sunflower seeds: The sources. Eur Food Res Technol. 2010;231:209-13.
Biedermann M, Grob K, Frijhlich D, Meier W. On-line coupled liquid chromatography-gas chromatography (LC-GC) and LC-LC-GC for detecting irradiation of fat-containing foods. Z Leb Unters Forsch. 1992;195:409-16.
Grob K, Huber M, Boderius U, Bronz M. Mineral oil material in canned foods. Food Addit Contam. 1997;14:83-8.
Fiorini D, Fiselier K, Biedermann M, Ballini R, Coni E, Grob K. Contamination of grape seed oil with mineral oil paraffins. J Agric Food Chem. 2008;56:11245-50.
Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38:317-25.
Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008;46:544-52.
Lommatzsch M, Biedermann M, Simat TJ, Grob K. Argentation high performance liquid chromatography on-line coupled to gas chromatography for the analysis of monounsaturated polyolefin oligomers in packaging materials and foods. J Chromatogr A. 2015;1402:94-101.
Liu Z, Phillips JB. Comprehensive two-dimensional gas chromatography using an on-column thermal modulator interface. J Chromatogr Sci. 1991;29:227-31.
Tranchida PQ, Purcaro G, Maimone M, Mondello L. Impact of comprehensive two-dimensional gas chromatography with mass spectrometry on food analysis. J Sep Sci. 2016;39:149-61.
Tranchida PQ, Purcaro G, Dugo P, Mondello L, Purcaro G. Modulators for comprehensive two-dimensional gas chromatography. Trends Anal Chem. 2011;30:1437-61.
Vendeuvre C, Ruiz-Guerrero R, Bertoncini F, Duval L, Thiébaut D. Comprehensive two-dimensional gas chromatography for detailed characterisation of petroleum products. Oil Gas Sci Technol. 2007;62:43-55.
Lommatzsch M, Biedermann M, Grob K, Simat TJ. Analysis of saturated and aromatic hydrocarbons migrating from a polyolefin-based hot-melt adhesive into food. Food Addit Contam. 2016;33:473-88.
Van Der Westhuizen R, Crous R, Villiers A De Sandra P. Comprehensive two-dimensional gas chromatography for the analysis of Fischer-Tropsch oil products. J Chromatogr A. 2010;1217:8334-39.
Van Der Westhuizen R, Ajam M, Coning P De Beens J, Villiers A De Sandra P. Comprehensive two-dimensional gas chromatography for the analysis of synthetic and crude-derived jet fuels. J Chromatogr A. 2011;1218:4478-86.
Biedermann M, Grob K. Comprehensive two-dimensional gas chromatography for characterizing mineral oils in foods and distinguishing them from synthetic hydrocarbons. J Chromatogr A. 2015;1375:146-53.
McCombie G, Hötzer K, Daniel J, Biedermann M, Eicher A, Grob K. Compliance work for polyolefins in food contact: Results of an official control campaign. Food Control. 2016;59:793-800.
Purcaro G, Tranchida PQ, Barp L, Moret S, Conte LS, Mondello L. Detailed elucidation of hydrocarbon co in food products by using solid-phase extraction and comprehensive gas chromatography with dual detection. Anal Chim Acta. 2013;773:97-104.
Panto’ S, Collard M, Purcaro G. Comprehensive gas chromatography coupled to simultaneous dual detection (TOF-MS/FID) as a confirmatory method for MOSH and MOAH determination in food. Curr Trend Mass Spectrom. 2020;18:1-6.
Purcaro G, 9th International Symposium on Recent Advances in Food Analysis, November 5-8, 2019, Prague.
European Parliament and the Council of the European Union. Commission decision of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results (notified under document number C(2002) 3044) (text with EEA relevance) (2002/657/EC). Off J Eur Commun. 2002:8-36.
Spack LW, Leszczyk G, Varela J, Simian H, Gude T, Stadler RH. Understanding the contamination of food with mineral oil: The need for a confirmatory analytical and procedural approach. Food Addit Contam. 2017;34:1052-71.
Koster S, Varela J, Stadler RH, Moulin J, Cruz-Hernandez C, Hielscher J, Lesueur C, Roïz J, Simian H. Mineral oil hydrocarbons in foods: Is the data reliable? Food Addit Contam. 2020;37:69-83.
Biedermann M, McCombie G, Grob K, Kappenstein O, Hutzler C, Pfaff K, Luch A. FID or MS for mineral oil analysis? J fur Verbraucherschutz und Leb. 2017;12:363-65.