Azithromycin Differentially Alters TCR-Activated Helper T Cell Subset Phenotype and Effector Function.
Anti-Bacterial Agents
/ pharmacology
Azithromycin
/ pharmacology
Bacterial Infections
/ drug therapy
Cell Differentiation
Cell Movement
Cells, Cultured
Healthy Volunteers
Humans
Interferon-gamma
/ metabolism
Interleukin-4
/ metabolism
Receptors, Antigen, T-Cell
/ metabolism
Receptors, CCR4
/ metabolism
Receptors, CXCR3
/ metabolism
T-Lymphocyte Subsets
/ drug effects
Th1 Cells
/ drug effects
CCR4
CD4+ helper T cells
CXCR3
IFN-γ
IL-4
anti-inflammatory
apoptosis
azithromycin
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
04
2020
accepted:
31
08
2020
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
4
6
2021
Statut:
epublish
Résumé
In addition to their antibiotic activities, azithromycin (AZM) exhibits anti-inflammatory effects in various respiratory diseases. One of the potent anti-inflammatory mechanisms is through inhibition of CD4+ helper T (Th) cell effector function. However, their impact on specific Th subset is obscure. Herein, we demonstrate the cellular basis of phenotypic and functional alterations associated with Th subsets following AZM treatment
Identifiants
pubmed: 33117343
doi: 10.3389/fimmu.2020.556579
pmc: PMC7575909
doi:
Substances chimiques
Anti-Bacterial Agents
0
CCR4 protein, human
0
CXCR3 protein, human
0
Receptors, Antigen, T-Cell
0
Receptors, CCR4
0
Receptors, CXCR3
0
Interleukin-4
207137-56-2
Interferon-gamma
82115-62-6
Azithromycin
83905-01-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
556579Informations de copyright
Copyright © 2020 Ansari, Sharif-Askari, Jayakumar, Mohammed, Sharif-Askari, Venkatachalam, Mahboub, Schmidt, Hamoudi, Halwani and Hamid.
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