Hypoxia Promotes Syndecan-3 Expression in the Tumor Microenvironment.
cancer immunotherapy
hypoxia
solid tumors
syndecan-3
tumor microenvironment (TME)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
07
2020
accepted:
10
09
2020
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
16
6
2021
Statut:
epublish
Résumé
The syndecan (Sdc) family is comprised of four members of cell surface molecules (Sdc-1 to 4) with different biological functions. Syndecan-3 (Sdc-3) is known to be mainly expressed in the brain and nervous tissue and plays a key role in development, cell adhesion, and migration. Recent studies point to important roles for Sdc-3 in inflammatory disease, but the patterns of expression and significance of Sdc-3 in cancer remains unexplored. Here we show that Sdc-3 expression is upregulated on several cancer types, especially in solid tumors that are known to be hypoxic. The Cancer Genome Atlas program (TCGA) data demonstrated that Sdc-3 expression in the tumor microenvironment positively correlates with a hypoxia gene signature. To confirm a potential cause-effect, we performed experiments with tumor cell lines showing increased expression upon
Identifiants
pubmed: 33117401
doi: 10.3389/fimmu.2020.586977
pmc: PMC7561406
doi:
Substances chimiques
SDC3 protein, human
0
Syndecan-3
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
586977Informations de copyright
Copyright © 2020 Prieto-Fernández, Egia-Mendikute, Bosch, García del Río, Jimenez-Lasheras, Antoñana-Vildosola, Lee and Palazon.
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