Red cell distribution width and its association with retinopathy of prematurity.
Premature infants
Red cell distribution width (RDW)
Retinopathy of prematurity (ROP)
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
17
03
2020
accepted:
17
10
2020
pubmed:
30
10
2020
medline:
22
6
2021
entrez:
29
10
2020
Statut:
ppublish
Résumé
The aim of this study was to evaluate whether there is a relationship between red cell distribution width (RDW) values and the development of retinopathy of prematurity (ROP) in premature infants. This retrospective study was conducted on a total of 159 infants with gestational age (GA) < 35 weeks including 77 infants diagnosed as ROP (patients' group) and 82 infants without ROP (control group) between September 2015 and January 2018. RDW values of the preterm infants were obtained from their medical records (routine postpartum cord blood sample and follow-up venous blood samples taken at first week, second week and first month). The possible relationship between RDW values and clinical features of ROP development was evaluated. The mean GA of all infants was 29.2 ± 2.4 (24-35) weeks, and the mean birth weight was 1268 ± 419 (550-2500) g. The RDW values measured in the first and the second weeks were significantly higher in infants with ROP compared with those wihout ROP (p < .001 for both). There was no statistically significant difference between the groups in terms of cord blood and first month RDW values (p = .719, p = .108, respectively). The first and second week's RDW values of infants with ROP requiring treatment (severe ROP) were significantly higher than those of infants with ROP not requiring treatment (mild ROP) (p = .005, p = .031, respectively), but no statistically significant difference was observed between the groups in terms of cord blood and first month values (p = .114 and p = .371, respectively). RDW is an easily accessible and inexpensive marker that may reflect the clinical risk factors for ROP. Follow-up measures of RDW have the potential to help clinicians for the prediction of ROP development in the first 2 weeks postnatally.
Identifiants
pubmed: 33118094
doi: 10.1007/s10792-020-01627-7
pii: 10.1007/s10792-020-01627-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
699-706Références
Alon T, Hemo I, Itin A et al (1995) Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1:1024–1028
doi: 10.1038/nm1095-1024
Aikawa H, Noro M (2013) Low incidence of sight-threatening retinopathy of prematurity in infants born before 28 weeks gestation at a neonatal intensive care unit in Japan. Tohoku J Exp Med 230:185–190
doi: 10.1620/tjem.230.185
Palmer EA (1990) Results of U.S. randomized clinical trial of cryotherapy for ROP (CRYO-ROP). Doc Ophthalmic 74:245–251
doi: 10.1007/BF02482615
Early Treatment for Retinopathy of Prematurity Cooperative Group (2003) Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 121:1684–1694
doi: 10.1001/archopht.121.12.1684
Section on Ophthalmology American Academy of Pediatrics; American Academy of Ophthalmology; American Association for Pediatric Ophthalmology and Strabismus (2006) Screening examination of premature infants for retinopathy of prematurity. Pediatrics 117:572–576
doi: 10.1542/peds.2005-2749
Goldstein GP, Leonard SA, Kan P et al (2019) Prenatal and postnatal inflammation-related risk factors for retinopathy of prematurity. J Perinatol 39:964–973
doi: 10.1038/s41372-019-0357-2
Montagnana M, Cervellin G, Meschi T et al (2012) The role of red blood cell distribution width in cardiovascular and thrombotic disorders. ClinChem Lab Med 50:635–641
Felker GM, Allen LA, Pocock SJ et al (2007) Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 50:40–47
doi: 10.1016/j.jacc.2007.02.067
Clarke K, Sagunarthy R, Kansal S (2008) RDW as an additional marker in inflammatory bowel disease/undifferentiated colitis. Dig Dis Sci 53:2521–2523
doi: 10.1007/s10620-007-0176-8
Yunchun L, Yue W, Jun FZ et al (2016) Clinical significance of red blood cell distribution width and inflammatory factors for the disease activity in rheumatoid arthritis. Clin Lab 62:2327–2331
doi: 10.7754/Clin.Lab.2016.160406
Garofoli F, Ciardelli L, Mazzucchelli I et al (2014) The red cell distribution width (RDW): value and role in preterm, IUGR (intrauterine growth restricted), full-term infants. Hematology 19:365–369
doi: 10.1179/1607845413Y.0000000141
International Committee for the Classification of Retinopathy of Prematurity (2005) The international classification of retinopathy of prematurity revisited. Arch Ophthalmol 123:991–999
doi: 10.1001/archopht.123.7.991
Holm M, Morken TS, Fichorova RN et al (2017) ELGAN Study Neonatology and Ophthalmology Committees. Systemic Inflammation-Associated Proteins and Retinopathy of Prematurity in Infants Born Before the 28th Week of Gestation. Invest Ophthalmol Vis Sci 58:6419–6428
doi: 10.1167/iovs.17-21931
Lee J, Dammann O (2012) Perinatal infection, inflammation, and retinopathy of prematurity. Semin Fetal Neonatal Med 17:26–29
doi: 10.1016/j.siny.2011.08.007
Alter BP, Goldberg JD, Berkowitz RL (1988) Red cell size heterogeneity during ontogeny. Am J Pediatr Hematol Oncol 10:279–282
doi: 10.1097/00043426-198824000-00001
Said AS, Spinella PC, Hartman ME et al (2017) RBC distribution width: biomarker for red cell dysfunction and critical illness outcome? Pediatr Crit Care Med 18:134–142
doi: 10.1097/PCC.0000000000001017
Hartnett ME, Penn JS (2012) Mechanisms and management of retinopathy of prematurity. N Engl J Med 367:2515–2526
doi: 10.1056/NEJMra1208129
Akyüz Ünsal Aİ, Key Ö, Güler D et al (2020) Can complete blood count parameters predict retinopathy of prematurity? Turk J Ophthalmol 50(2):87–93
doi: 10.4274/tjo.galenos.2019.45313
De Haan TR, Beckers L, de Jonge RC et al (2013) Neonatal gram negative and Candida sepsis survival and neurodevelopmental outcome at the corrected age of 24 months. PLoS ONE 8:e59214
doi: 10.1371/journal.pone.0059214
Bas AY, Demirel N, Koc E et al (2018) TR-ROP Study Group. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units. Br J Ophthalmol 102:1711–1716
doi: 10.1136/bjophthalmol-2017-311789
Christensen RD, Yaish HM, Henry E et al (2015) Red blood cell distribution width: reference intervals for neonates. J Matern Fetal Neonatal Med 28:883–888
doi: 10.3109/14767058.2014.938044
Perente I, Eris E, Seymen Z, Cevik SG, Bekmez S (2019) Aggressive posterior retinopathy of prematurity treated with intravitreal bevacizumab: late period fluorescein angiographic findings. Graefes Arch Clin Exp Ophthalmol 257:1141–1146
doi: 10.1007/s00417-019-04292-4