Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach.
Adult
Affect
/ physiology
Anxiety Disorders
/ physiopathology
Auditory Perception
/ physiology
Avoidance Learning
/ physiology
Conflict, Psychological
Decision Making
/ physiology
Depressive Disorder
/ physiopathology
Female
Humans
Longitudinal Studies
Male
Middle Aged
Models, Theoretical
Pattern Recognition, Visual
/ physiology
Psychomotor Performance
/ physiology
Reward
Substance-Related Disorders
/ physiopathology
Uncertainty
Young Adult
Journal
Journal of psychiatry & neuroscience : JPN
ISSN: 1488-2434
Titre abrégé: J Psychiatry Neurosci
Pays: Canada
ID NLM: 9107859
Informations de publication
Date de publication:
04 01 2021
04 01 2021
Historique:
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
29
10
2021
Statut:
epublish
Résumé
Imbalances in approach-avoidance conflict (AAC) decision-making (e.g., sacrificing rewards to avoid negative outcomes) are considered central to multiple psychiatric disorders. We used computational modelling to examine 2 factors that are often not distinguished in descriptive analyses of AAC: decision uncertainty and sensitivity to negative outcomes versus rewards (emotional conflict). A previously validated AAC task was completed by 478 participants, including healthy controls ( The model showed high accuracy (72%). As further validation, parameters correlated with reaction times and self-reported task motivations in expected directions. The emotional conflict parameter further correlated with self-reported anxiety during the task ( This study was limited by heterogeneity of the clinical sample and an inability to examine learning. These results suggest that reduced confidence in how to act, rather than increased emotional conflict, may explain maladaptive approach-avoidance behaviours in people with psychiatric disorders.
Sections du résumé
BACKGROUND
Imbalances in approach-avoidance conflict (AAC) decision-making (e.g., sacrificing rewards to avoid negative outcomes) are considered central to multiple psychiatric disorders. We used computational modelling to examine 2 factors that are often not distinguished in descriptive analyses of AAC: decision uncertainty and sensitivity to negative outcomes versus rewards (emotional conflict).
METHODS
A previously validated AAC task was completed by 478 participants, including healthy controls (
RESULTS
The model showed high accuracy (72%). As further validation, parameters correlated with reaction times and self-reported task motivations in expected directions. The emotional conflict parameter further correlated with self-reported anxiety during the task (
LIMITATIONS
This study was limited by heterogeneity of the clinical sample and an inability to examine learning.
CONCLUSION
These results suggest that reduced confidence in how to act, rather than increased emotional conflict, may explain maladaptive approach-avoidance behaviours in people with psychiatric disorders.
Identifiants
pubmed: 33119490
pii: 10.1503/jpn.200032
doi: 10.1503/jpn.200032
pmc: PMC7955838
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
E74-E87Subventions
Organisme : NIMH NIH HHS
ID : K23 MH108707
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121312
Pays : United States
Informations de copyright
© 2021 Joule Inc. or its licensors
Déclaration de conflit d'intérêts
None declared.
Références
Neuropsychopharmacology. 2010 Jan;35(1):217-38
pubmed: 19710631
Behav Res Ther. 2017 Sep;96:14-29
pubmed: 28495358
Soc Cogn Affect Neurosci. 2017 Mar 1;12(3):468-475
pubmed: 27694531
Neuroimage. 2018 Apr 1;169:323-333
pubmed: 29221752
Behav Brain Res. 2011 Dec 1;225(2):455-63
pubmed: 21843556
J Neurosci. 2009 Nov 18;29(46):14617-26
pubmed: 19923294
Nat Commun. 2016 Mar 29;7:10996
pubmed: 27020312
Arch Gen Psychiatry. 2004 Apr;61(4):354-60
pubmed: 15066893
Netw Neurosci. 2017;1(4):381-414
pubmed: 29417960
Q J Exp Psychol A. 1988 Nov;40(4):801-12
pubmed: 3212213
Drug Alcohol Depend. 2020 Oct 1;215:108208
pubmed: 32801113
Hum Brain Mapp. 2015 Feb;36(2):449-62
pubmed: 25224633
Biol Psychiatry. 2017 Sep 15;82(6):440-446
pubmed: 28838468
Behav Res Ther. 1998 Feb;36(2):215-26
pubmed: 9613027
PLoS One. 2017 Jul 31;12(7):e0181955
pubmed: 28759635
Psychol Med. 2018 Oct;48(14):2277-2284
pubmed: 29478431
Science. 1997 Feb 28;275(5304):1293-5
pubmed: 9036851
Front Neuroendocrinol. 2014 Aug;35(3):320-30
pubmed: 24887405
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
Sci Rep. 2017 Nov 7;7(1):14678
pubmed: 29116142
Trends Cogn Sci. 2012 Sep;16(9):476-83
pubmed: 22898207
Am J Psychiatry. 2010 Jul;167(7):748-51
pubmed: 20595427
Trends Cogn Sci. 2012 Jan;16(1):72-80
pubmed: 22177032
Biol Psychiatry. 2017 Sep 15;82(6):421-430
pubmed: 28619481
JMIR Ment Health. 2020 Jan 28;7(1):e16919
pubmed: 32012081
PLoS One. 2010 Dec 14;5(12):e15554
pubmed: 21179480
Drug Alcohol Depend. 2014 Sep 1;142:110-9
pubmed: 24993186
Neural Comput. 2015 Feb;27(2):306-28
pubmed: 25514108
Pharmacol Biochem Behav. 2018 Jan;164:84-98
pubmed: 28666893
Neuroimage Clin. 2019;22:101738
pubmed: 30870735
Neuropsychology. 2017 Mar;31(3):311-318
pubmed: 28054825
Cereb Cortex. 2015 Oct;25(10):3434-45
pubmed: 25056572
Philos Trans R Soc Lond B Biol Sci. 2014 Nov 5;369(1655):
pubmed: 25267823
Neural Comput. 2021 Feb;33(2):398-446
pubmed: 33253028
Psychol Addict Behav. 2007 Sep;21(3):409-14
pubmed: 17874892
J Abnorm Psychol. 1998 May;107(2):285-90
pubmed: 9604557
Elife. 2020 Apr 07;9:
pubmed: 32254020
PLoS Comput Biol. 2012 Jan;8(1):e1002327
pubmed: 22241972
Addiction. 2001 Nov;96(11):1615-28
pubmed: 11784458
eNeuro. 2016 Aug 02;3(4):
pubmed: 27517087
Sci Rep. 2019 Jan 23;9(1):419
pubmed: 30674933
Neuroimage. 2016 Aug 1;136:94-105
pubmed: 27153979
JAMA Psychiatry. 2017 Dec 1;74(12):1185-1186
pubmed: 29094142
Behav Brain Res. 2015 Apr 15;283:121-38
pubmed: 25639540
J Behav Ther Exp Psychiatry. 2007 Jun;38(2):105-20
pubmed: 17126289
Br J Clin Psychol. 2005 Jun;44(Pt 2):193-207
pubmed: 16004654
Neural Comput. 2017 Jan;29(1):1-49
pubmed: 27870614
Neuroimage. 2009 Jul 15;46(4):1004-17
pubmed: 19306932
Dialogues Clin Neurosci. 2010;12(4):517-31
pubmed: 21319496
Front Hum Neurosci. 2019 Feb 26;13:56
pubmed: 30863294
J Abnorm Psychol. 2001 Feb;110(1):40-8
pubmed: 11261398
Drug Alcohol Depend. 2013 Nov 1;133(1):86-93
pubmed: 23791040
Psychol Sci. 2011 Apr;22(4):490-7
pubmed: 21389338
Am J Psychiatry. 2011 May;168(5):540-9
pubmed: 21362742
J Exp Psychol Appl. 2002 Jun;8(2):75-84
pubmed: 12075692
PLoS Comput Biol. 2013;9(6):e1003094
pubmed: 23785269
Lancet Psychiatry. 2014 Jul;1(2):148-58
pubmed: 26360579
Psychol Addict Behav. 2008 Sep;22(3):444-9
pubmed: 18778139
Arch Clin Neuropsychol. 1996;11(6):513-9
pubmed: 14588456
Behav Brain Res. 2010 Dec 1;213(2):135-41
pubmed: 20420859
Neurosci Biobehav Rev. 2019 Dec;107:473-491
pubmed: 31518636
Nat Neurosci. 2016 Mar;19(3):404-13
pubmed: 26906507
Prog Brain Res. 2014;211:31-77
pubmed: 24968776
Arch Gen Psychiatry. 1998 May;55(5):405-13
pubmed: 9596043
BMJ Open. 2018 Jan 24;8(1):e016620
pubmed: 29371263
Front Psychol. 2019 Dec 19;10:2844
pubmed: 31920873
Neurosci Biobehav Rev. 2016 Sep;68:862-879
pubmed: 27375276
Neuroimage Clin. 2020;26:102244
pubmed: 32193171
JAMA Psychiatry. 2019 May 1;76(5):545-547
pubmed: 30840037
Gend Med. 2007;4 Suppl B:S178-93
pubmed: 18156102
Psychol Med. 1996 Sep;26(5):975-89
pubmed: 8878330
Depress Anxiety. 2006;23(4):245-9
pubmed: 16688739
Neuroimage. 2007 Jan 1;34(1):220-34
pubmed: 17055746
Am J Psychiatry. 2009 Jan;166(1):50-7
pubmed: 19047325
Cogn Emot. 2015;29(8):1424-44
pubmed: 25491372
Front Aging Neurosci. 2018 Oct 24;10:317
pubmed: 30405393
Behav Ther. 2016 Nov;47(6):838-853
pubmed: 27993336
J Gen Intern Med. 2001 Sep;16(9):606-13
pubmed: 11556941
Neuropsychopharmacology. 2019 Mar;44(4):695-702
pubmed: 30181595
Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Aug;4(8):734-742
pubmed: 31053534
Prog Neurobiol. 2017 Sep;156:164-188
pubmed: 28576664
Soc Sci Med. 2008 Mar;66(6):1334-45
pubmed: 18234406
Front Aging Neurosci. 2018 Jul 02;10:184
pubmed: 30013472
Front Comput Neurosci. 2015 Nov 04;9:136
pubmed: 26581305
Neuroimage. 2014 Jan 1;84:971-85
pubmed: 24018303
Neural Comput. 2017 Oct;29(10):2633-2683
pubmed: 28777724
Addict Biol. 2020 Nov;25(6):e12831
pubmed: 31617639