Development and preclinical evaluation of cixutumumab drug conjugates in a model of insulin growth factor receptor I (IGF-1R) positive cancer.

Animals Antibodies, Monoclonal, Humanized / pharmacology Cell Line, Tumor Female Humans Immunoconjugates / pharmacology Insulin / metabolism MCF-7 Cells Mice, Nude Neoplasms / drug therapy Receptor, IGF Type 1 / metabolism

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
29 10 2020
Historique:
received: 09 09 2019
accepted: 29 09 2020
entrez: 30 10 2020
pubmed: 31 10 2020
medline: 5 3 2021
Statut: epublish

Résumé

Overexpression of insulin growth factor receptor type 1 (IGF-1R) is observed in many cancers. Antibody drug conjugates (ADCs) with PEGylated maytansine (PEG

Identifiants

DOI: 10.1038/s41598-020-75279-z PMID: 33122707 PMC: PMC7596529
pubmed: 33122707
doi: 10.1038/s41598-020-75279-z
pii: 10.1038/s41598-020-75279-z
pmc: PMC7596529
doi:

Substances chimiques

Antibodies, Monoclonal, Humanized 0
Immunoconjugates 0
Insulin 0
cixutumumab 2285XW22DR
Receptor, IGF Type 1 EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

18549

Références

Cancer Res. 2005 Dec 1;65(23):11118-28
pubmed: 16322262
Clin Cancer Res. 2007 Sep 15;13(18 Pt 2):5549s-5555s
pubmed: 17875788
Breast Cancer Res Treat. 2012 Aug;135(1):189-200
pubmed: 22736376
Invest New Drugs. 2015 Apr;33(2):450-62
pubmed: 25749986
Breast Cancer Res Treat. 1992;24(2):85-95
pubmed: 8095168
J Nucl Med. 2009 Apr;50(4):599-605
pubmed: 19289425
Clin Cancer Res. 2010 Oct 1;16(19):4769-78
pubmed: 20805300
J Nucl Med. 2014 Aug;55(8):1368-74
pubmed: 24904110
N Engl J Med. 2012 Nov 8;367(19):1783-91
pubmed: 23020162
Ann Oncol. 2011 Jan;22(1):68-73
pubmed: 20647220
Ann Oncol. 2017 Dec 1;28(12):3037-3043
pubmed: 28950351
Cancer Res. 1990 Jan 1;50(1):48-53
pubmed: 2152773
Bioconjug Chem. 2014 Apr 16;25(4):656-64
pubmed: 24559399
J Clin Invest. 1989 Nov;84(5):1418-23
pubmed: 2553774
J Nucl Med. 2010 Oct;51(10):1565-72
pubmed: 20847162
J Cell Physiol. 2013 Apr;228(4):675-9
pubmed: 22926508
Cell. 2010 Apr 2;141(1):69-80
pubmed: 20371346
Mol Pharm. 2019 Dec 2;16(12):4807-4816
pubmed: 31518138
J Med Chem. 2011 May 26;54(10):3606-23
pubmed: 21517041
Front Pharmacol. 2013 Mar 22;4:30
pubmed: 23525758
Mol Pharm. 2012 Jul 2;9(7):2000-8
pubmed: 22621404
Pharm Res. 2014 Jul;31(7):1710-23
pubmed: 24464270
J Clin Oncol. 2017 Jan 10;35(2):141-148
pubmed: 28056202
J Thorac Oncol. 2017 Feb;12(2):383-389
pubmed: 27464970
Cancer Res. 2008 Nov 15;68(22):9280-90
pubmed: 19010901
Oncotarget. 2018 Mar 30;9(24):17117-17132
pubmed: 29682209
Curr Drug Targets. 2011 Dec;12(14):2016-33
pubmed: 21777192
Eur J Med Chem. 2018 Sep 5;157:437-446
pubmed: 30103192
Mol Cancer Ther. 2006 Jun;5(6):1474-82
pubmed: 16818506
Nucl Med Biol. 2008 Aug;35(6):645-53
pubmed: 18678349
Oncotarget. 2019 Feb 1;10(10):1031-1044
pubmed: 30800216
J Immunol Methods. 1984 Aug 3;72(1):77-89
pubmed: 6086763
N Engl J Med. 2019 Feb 14;380(7):617-628
pubmed: 30516102
J Nucl Med. 2019 Aug;60(8):1103-1110
pubmed: 30655327
Clin Cancer Res. 2004 Dec 1;10(23):7842-51
pubmed: 15585616
Nat Biotechnol. 2012 Oct;30(10):906-7
pubmed: 23051797
Cancer Res. 2010 Mar 15;70(6):2528-37
pubmed: 20197459
Horm Cancer. 2014 Aug;5(4):232-9
pubmed: 24849545
Pharm Res. 2015 Nov;32(11):3577-83
pubmed: 26108878
Clin Cancer Res. 2011 Oct 15;17(20):6437-47
pubmed: 22003071
Breast Cancer Res. 2014 Mar 05;16(2):209
pubmed: 24887180
J Natl Cancer Inst. 2001 Dec 19;93(24):1852-7
pubmed: 11752009
Drug Resist Updat. 2015 Jan;18:36-46
pubmed: 25476546

Auteurs

Viswas Raja Solomon (VR)

Department of Medical Imaging, RUH Saskatoon, University of Saskatchewan, College of Medicine, 103 Hospital Dr., Saskatoon, SK, S7N 0W8, Canada.

Elahe Alizadeh (E)

Department of Medical Imaging, RUH Saskatoon, University of Saskatchewan, College of Medicine, 103 Hospital Dr., Saskatoon, SK, S7N 0W8, Canada.

Wendy Bernhard (W)

Department of Pathology and Laboratory Medicine, University of Saskatchewan, College of Medicine, Saskatoon, SK, Canada.

Amal Makhlouf (A)

Department of Medical Imaging, RUH Saskatoon, University of Saskatchewan, College of Medicine, 103 Hospital Dr., Saskatoon, SK, S7N 0W8, Canada.
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo, 12411, Egypt.

Siddesh V Hartimath (SV)

Department of Medical Imaging, RUH Saskatoon, University of Saskatchewan, College of Medicine, 103 Hospital Dr., Saskatoon, SK, S7N 0W8, Canada.

Wayne Hill (W)

Department of Pathology and Laboratory Medicine, University of Saskatchewan, College of Medicine, Saskatoon, SK, Canada.

Ayman El-Sayed (A)

Department of Pathology and Laboratory Medicine, University of Saskatchewan, College of Medicine, Saskatoon, SK, Canada.

Kris Barreto (K)

Department of Pathology and Laboratory Medicine, University of Saskatchewan, College of Medicine, Saskatoon, SK, Canada.

Clarence Ronald Geyer (CR)

Department of Pathology and Laboratory Medicine, University of Saskatchewan, College of Medicine, Saskatoon, SK, Canada.
ORCID: 0000-0003-1628-9665

Humphrey Fonge (H)

Department of Medical Imaging, RUH Saskatoon, University of Saskatchewan, College of Medicine, 103 Hospital Dr., Saskatoon, SK, S7N 0W8, Canada. humphrey.fonge@usask.ca.
Department of Medical Imaging, Royal University Hospital Saskatoon, Saskatoon, SK, Canada. humphrey.fonge@usask.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Development and preclinical evaluation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › Development and preclinical evaluation of...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Development and preclinical evaluation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Development and preclinical evaluation of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunoconjugués › Development and preclinical evaluation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Development and preclinical evaluation of...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cellules MCF-7 › Development and preclinical evaluation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Development and preclinical evaluation of...
questionsmedicales.fr › Tumeurs › Development and preclinical evaluation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs des somatomédines › Récepteur IGF de type 1 › Development and preclinical evaluation of...