Endocrine Requirements for Oocyte Maturation Following hCG, GnRH Agonist, and Kisspeptin During IVF Treatment.
Chorionic Gonadotropin
/ administration & dosage
Estradiol
/ blood
Female
Fertility Agents, Female
/ administration & dosage
Fertilization in Vitro
/ methods
Follicle Stimulating Hormone
/ blood
Humans
Kisspeptins
/ administration & dosage
Luteinizing Hormone
/ blood
Luteolytic Agents
/ administration & dosage
Oocytes
/ drug effects
Oogenesis
/ drug effects
Ovulation Induction
/ methods
Progesterone
/ blood
Retrospective Studies
Triptorelin Pamoate
/ administration & dosage
fertility
in vitro fertilization treatment
oocyte maturation
progesterone
trigger
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
02
2020
accepted:
09
09
2020
entrez:
30
10
2020
pubmed:
31
10
2020
medline:
22
5
2021
Statut:
epublish
Résumé
The maturation of oocytes to acquire competence for fertilization is critical to the success of Retrospective cohort study. Prospectively collected hormonal data from 499 research IVF cycles triggered with either hCG, GnRHa, or kisspeptin were evaluated. HCG-levels (121 iU/L) peaked at 24 h following hCG, whereas LH-levels peaked at ~4 h following GnRHa (140 iU/L), or kisspeptin (41 iU/L). HCG-levels were negatively associated with body-weight, whereas LH rises following GnRHa and kisspeptin were positively predicted by pre-trigger LH values. The odds of achieving the median mature oocyte yield for each trigger were increased by hCG/LH level. Progesterone rise during oocyte maturation occurred precipitously following each trigger and strongly predicted the number of mature oocytes retrieved. Progesterone rise was positively associated with the hCG-level following hCG trigger, but negatively with LH rise following all three triggers. The rise in progesterone per mature oocyte at 12 h was greater following GnRHa than following hCG or kisspeptin triggers. The endocrine response during oocyte maturation significantly differed by each trigger. Counter-intuitively, progesterone rise during oocyte maturation was negatively associated with LH rise, even when accounting for the number of mature oocytes retrieved. These data expand our understanding of the endocrine changes during oocyte maturation and inform the design of future precision-triggering protocols.
Identifiants
pubmed: 33123084
doi: 10.3389/fendo.2020.537205
pmc: PMC7573298
doi:
Substances chimiques
Chorionic Gonadotropin
0
Fertility Agents, Female
0
Kisspeptins
0
Luteolytic Agents
0
Triptorelin Pamoate
08AN7WA2G0
Progesterone
4G7DS2Q64Y
Estradiol
4TI98Z838E
Luteinizing Hormone
9002-67-9
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
537205Subventions
Organisme : Department of Health
ID : CS-2018-18-ST2-002
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M004171/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Department of Health
ID : CDF-2009-02-05
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000455
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Abbara, Hunjan, Ho, Clarke, Comninos, Izzi-Engbeaya, Ho, Trew, Hramyka, Kelsey, Salim, Humaidan, Vuong and Dhillo.
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