Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients.
Biomarkers
/ blood
Female
Flow Cytometry
Graft Rejection
/ blood
HLA Antigens
/ immunology
Histocompatibility
Histocompatibility Testing
Humans
Influenza Vaccines
/ adverse effects
Isoantibodies
/ blood
Longitudinal Studies
Male
Middle Aged
Organ Transplantation
/ adverse effects
Prospective Studies
Risk Assessment
Risk Factors
Spain
Time Factors
Treatment Outcome
Vaccination
alloreactivity
anti-human leukocyte antigen
cytomegalovirus
donor specific antibodies
organ rejection
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
03
2020
accepted:
16
07
2020
entrez:
30
10
2020
pubmed:
31
10
2020
medline:
20
4
2021
Statut:
epublish
Résumé
Our goal was to study whether influenza vaccination induced antibody mediated rejection in a large cohort of solid organ transplant recipients (SOTR). Serum anti-Human Leukocyte Antigen (HLA) antibodies were determined using class I and class II antibody-coated latex beads (FlowPRA We studied a cohort of 490 SOTR that received an influenza vaccination from 2009 to 2013: 110 (22.4%) received the pandemic adjuvanted vaccine, 59 (12%) within the first 6 months post-transplantation, 185 (37.7%) more than 6 months after transplantation and 136 (27.7%) received two vaccination doses. Overall, no differences of anti-HLA antibodies were found after immunization in patients that received the adjuvanted vaccine, within the first 6 months post-transplantation, or based on the type of organ transplanted. However, the second immunization dose increased the percentage of patients positive for anti-HLA class I significantly compared with patients with one dose (14.6% vs. 3.8%; Our results suggest that influenza vaccination is not associated with graft rejection in this cohort of SOTR.
Identifiants
pubmed: 33123119
doi: 10.3389/fimmu.2020.01917
pmc: PMC7574595
doi:
Substances chimiques
Biomarkers
0
HLA Antigens
0
Influenza Vaccines
0
Isoantibodies
0
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1917Informations de copyright
Copyright © 2020 Cordero, Bulnes-Ramos, Aguilar-Guisado, González Escribano, Olivas, Torre-Cisneros, Gavaldá, Aydillo, Moreno, Montejo, Fariñas, Carratalá, Muñoz, Blanes, Fortún, Suárez-Benjumea, López-Medrano, Roca, Lara and Pérez-Romero.
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