Non-conventional dysplasias of the tubular gut: a review and illustration of their histomorphological spectrum.
Barrett Esophagus
/ diagnosis
Colon
/ pathology
Diagnosis, Differential
Duodenum
/ pathology
Endoscopy, Gastrointestinal
/ methods
Gastritis, Atrophic
/ diagnosis
Gastrointestinal Diseases
/ diagnosis
Gastrointestinal Microbiome
Gastrointestinal Tract
/ pathology
Humans
Inflammatory Bowel Diseases
/ diagnosis
Practice Guidelines as Topic
Precancerous Conditions
/ diagnosis
Barrett oesophagus
colon
duodenum
dysplasia
gastric
gastrointestinal
inflammatory bowel disease
Journal
Histopathology
ISSN: 1365-2559
Titre abrégé: Histopathology
Pays: England
ID NLM: 7704136
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
pubmed:
31
10
2020
medline:
27
10
2021
entrez:
30
10
2020
Statut:
ppublish
Résumé
The increasing use of gastrointestinal endoscopic procedures has led to the recognition by histopathologists of non-conventional (or special-type) dysplasias of the gastrointestinal tract. These lesions can be recognised in association with prevalent underlying gastrointestinal conditions, such as Barrett oesophagus, chronic atrophic gastritis, and inflammatory bowel disease. The diagnosis of these special types can be challenging, and their biological behaviours are not fully characterised. The aim of this review is to provide a global view of non-conventional dysplastic lesions observed in the various segments of the tubular gastrointestinal tract and describe their salient features. Furthermore, as the clinical implications of these various subtypes have not been broadly tested in practice and are not represented in most management guidelines, we offer guidance on the best management practices for these lesions.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
658-675Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
WHO Classification of Tumours Editorial Board eds. World Health Organization classification of tumours: digestive system tumours. 5th ed. Lyon: IARC Press, 2019; 33, 74, 113.
Brown IS, Whiteman DC, Lauwers GY. Foveolar type dysplasia in Barrett esophagus. Mod. Pathol. 2010; 23; 834-843.
Rucker-Schmidt RL, Sanchez CA, Blount PL et al. Nonadenomatous dysplasia in Barrett esophagus: a clinical, pathologic, and DNA content flow cytometric study. Am. J. Surg. Pathol. 2009; 33; 886-893.
Park DY, Srivastava A, Kim GH et al. Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia. Am. J. Surg. Pathol. 2008; 32; 524-533.
Takubo K, Aida J, Naomoto Y et al. Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma. Hum. Pathol. 2009; 40; 65-74.
Kelty CJ, Gough MD, Van Wyk Q, Stephenson TJ, Ackroyd R. Barrett's oesophagus: intestinal metaplasia is not essential for cancer risk. Scand. J. Gastroenterol. 2007; 42; 1271-1274.
Mahajan D, Bennett AE, Liu X, Bena J, Bronner MP. Grading of gastric foveolar-type dysplasia in Barrett's esophagus. Mod. Pathol. 2010; 23; 1-11.
Vennalaganti P, Kanakadandi V, Goldblum JR et al. Discordance among pathologists in the United States and Europe in diagnosis of low-grade dysplasia for patients with Barrett's esophagus. Gastroenterology 2017; 152; 564-570.
Nagtegaal ID, Odze RD, Klimstra D et al. The 2019 WHO classification of tumours of the digestive system. Histopathology 2020; 76; 182-188.
Vieth M, Montgomery EA, Riddell RH. Observations of different patterns of dysplasia in Barretts esophagus - a first step to harmonize grading. Ceskoslovenska Patol. 2016; 52; 154-163.
Naini BV, Souza RF, Odze RD. Barrett's esophagus: a comprehensive and contemporary review for pathologists. Am. J. Surg. Pathol. 2016; 40; e45-e66.
Srivastava A, Sanchez CA, Cowan DS et al. Foveolar and serrated dysplasia are rare high-risk lesions in Barrett's esophagus: a prospective outcome analysis of 214 patients. Mod. Pathol. 2010; 23; 168a.
Lomo LC, Blount PL, Sanchez CA et al. Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort. Am. J. Surg. Pathol. 2006; 30; 423-435.
Zhang X, Huang Q, Goyal RK, Odze RD. DNA ploidy abnormalities in basal and superficial regions of the crypts in Barrett's esophagus and associated neoplastic lesions. Am. J. Surg. Pathol. 2008; 32; 1327-1335.
Reid BJ, Haggitt RC, Rubin CE et al. Observer variation in the diagnosis of dysplasia in Barrett's esophagus. Hum. Pathol. 1988; 19; 166-178.
Coco DP, Goldblum JR, Hornick JL et al. Interobserver variability in the diagnosis of crypt dysplasia in Barrett esophagus. Am. J. Surg. Pathol. 2011; 35; 45-54.
Sharma P, Montgomery E. Gastrointestinal dysplasia. Pathology 2013; 45; 273-285.
Thota PN, Kistangari G, Esnakula AK, Gonzalo DH, Liu XL. Clinical significance and management of Barrett's esophagus with epithelial changes indefinite for dysplasia. World J. Gastrointest. Pharmacol. Ther. 2016; 7; 406-411.
Odze RD. Diagnosis and grading of dysplasia in Barrett's oesophagus. J. Clin. Pathol. 2006; 59; 1029-1038.
Hagen CE, Lauwers GY, Mino-Kenudson M. Barrett esophagus: diagnostic challenges. Semin. Diagn. Pathol. 2014; 31; 100-113.
Khan S, McDonald SA, Wright NA et al. Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells. J. Pathol. 2013; 231; 98-104.
Hattori T. Morphological range of hyperplastic polyps and carcinomas arising in hyperplastic polyps of the stomach. J. Clin. Pathol. 1985; 38; 622-630.
Kushima R, Hattori T. Histogenesis and characteristics of gastric-type adenocarcinomas in the stomach. J. Cancer Res. Clin. Oncol. 1993; 120; 103-111.
Abraham SC, Park SJ, Mugartegui L, Hamilton SR, Wu TT. Sporadic fundic gland polyps with epithelial dysplasia: evidence for preferential targeting for mutations in the adenomatous polyposis coli gene. Am. J. Pathol. 2002; 161; 1735-1742.
Shibagaki K, Fukuyama C, Mikami H et al. Gastric foveolar-type adenomas endoscopically showing a raspberry-like appearance in the Helicobacter pylori-uninfected stomach. Endosc. Int. Open 2019; 7; E784-E791.
Abraham SC, Montgomery EA, Singh VK, Yardley JH, Wu TT. Gastric adenomas: intestinal-type and gastric-type adenomas differ in the risk of adenocarcinoma and presence of background mucosal pathology. Am. J. Surg. Pathol. 2002; 26; 1276-1285.
Valente P, Garrido M, Gullo I et al. Epithelial dysplasia of the stomach with gastric immunophenotype shows features of biological aggressiveness. Gastric Cancer 2015; 18; 720-728.
Serra S, Chetty R. Non-adenomatous forms of gastro-oesophageal epithelial dysplasia: an under-recognised entity? J. Clin. Pathol. 2014; 67; 898-902.
Serra S, Ali R, Bateman AC et al. Gastric foveolar dysplasia: a survey of reporting habits and diagnostic criteria. Pathology 2017; 49; 391-396.
Hida R, Yamamoto H, Hirahashi M et al. Duodenal neoplasms of gastric phenotype: an immunohistochemical and genetic study with a practical approach to the classification. Am. J. Surg. Pathol. 2017; 41; 343-353.
Wu TT, Kornacki S, Rashid A, Yardley JH, Hamilton SR. Dysplasia and dysregulation of proliferation in foveolar and surface epithelia of fundic gland polyps from patients with familial adenomatous polyposis. Am. J. Surg. Pathol. 1998; 22; 293-298.
Arnason T, Liang WY, Alfaro E et al. Morphology and natural history of familial adenomatous polyposis-associated dysplastic fundic gland polyps. Histopathology 2014; 65; 353-362.
Abraham SC, Nobukawa B, Giardiello FM, Hamilton SR, Wu TT. Fundic gland polyps in familial adenomatous polyposis: neoplasms with frequent somatic adenomatous polyposis coli gene alterations. Am. J. Pathol. 2000; 157; 747-754.
Worthley DL, Phillips KD, Wayte N et al. Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. Gut 2012; 61; 774-779.
de Boer WB, Ee H, Kumarasinghe MP. Neoplastic lesions of gastric adenocarcinoma and proximal polyposis syndrome (GAPPS) are gastric phenotype. Am. J. Surg. Pathol. 2018; 42; 1-8.
Abraham SC, Park SJ, Lee JH, Mugartegui L, Wu TT. Genetic alterations in gastric adenomas of intestinal and foveolar phenotypes. Mod. Pathol. 2003; 16; 786-795.
Matsubara A, Sekine S, Kushima R et al. Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum. J. Pathol. 2013; 229; 579-587.
Yao T, Utsunomiya T, Oya M, Nishiyama K, Tsuneyoshi M. Extremely well-differentiated adenocarcinoma of the stomach: clinicopathological and immunohistochemical features. World J. Gastroenterol. 2006; 12; 2510-2516.
Kushima R, Vieth M, Borchard F, Stolte M, Mukaisho K, Hattori T. Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach. Gastric Cancer 2006; 9; 177-184.
Rubio CA. Serrated neoplasia of the stomach: a new entity. J. Clin. Pathol. 2001; 54; 849-853.
Kwon MJ, Min BH, Lee SM et al. Serrated adenoma of the stomach: a clinicopathologic, immunohistochemical, and molecular study of nine cases. Histol. Histopathol. 2013; 28; 453-462.
Snover DC, Jass JR, Fenoglio-Preiser C, Batts KP. Serrated polyps of the large intestine: a morphologic and molecular review of an evolving concept. Am. J. Clin. Pathol. 2005; 124; 380-391.
Rubio CA. Traditional serrated adenomas of the upper digestive tract. J. Clin. Pathol. 2016; 69; 1-5.
Shin N, Jo HJ, Kim WK et al. Gastric pit dysplasia in adjacent gastric mucosa in 414 gastric cancers: prevalence and characteristics. Am. J. Surg. Pathol. 2011; 35; 1021-1029.
Agoston AT, Odze RD. Evidence that gastric pit dysplasia-like atypia is a neoplastic precursor lesion. Hum. Pathol. 2014; 45; 446-455.
Li Y, Chang X, Zhou W et al. Gastric intestinal metaplasia with basal gland atypia: a morphological and biologic evaluation in a large Chinese cohort. Hum. Pathol. 2013; 44; 578-590.
Tava F, Luinetti O, Ghigna MR et al. Type or extension of intestinal metaplasia and immature/atypical ‘indefinite-for-dysplasia’ lesions as predictors of gastric neoplasia. Hum. Pathol. 2006; 37; 1489-1497.
Chen ZM, Scudiere JR, Abraham SC, Montgomery E. Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma. Am. J. Surg. Pathol. 2009; 33; 186-193.
Vieth M, Kushima R, Borchard F, Stolte M. Pyloric gland adenoma: a clinico-pathological analysis of 90 cases. Virchows Arch. 2003; 442; 317-321.
Pezhouh MK, Park JY. Gastric pyloric gland adenoma. Arch. Pathol. Lab. Med. 2015; 139; 823-826.
Vieth M, Kushima R, Mukaisho K, Sakai R, Kasami T, Hattori T. Immunohistochemical analysis of pyloric gland adenomas using a series of mucin 2, mucin 5AC, mucin 6, CD10, Ki67 and p53. Virchows Arch. 2010; 457; 529-536.
Chlumská A, Waloschek T, Mukenšnabl P, Martínek P, Kašpírková J, Zámečník M. Pyloric gland adenoma: a histologic, immunohistochemical and molecular genetic study of 23 cases. Ceskoslovenska Patol. 2015; 51; 137-143.
Vieth M, Montgomery EA. Some observations on pyloric gland adenoma: an uncommon and long ignored entity!. J. Clin. Pathol. 2014; 67; 883-890.
Kushima R, Vieth M, Mukaisho K et al. Pyloric gland adenoma arising in Barrett's esophagus with mucin immunohistochemical and molecular cytogenetic evaluation. Virchows Arch. 2005; 446; 537-541.
Kushima R, Rüthlein HJ, Stolte M, Bamba M, Hattori T, Borchard F. ‘Pyloric gland-type adenoma’ arising in heterotopic gastric mucosa of the duodenum, with dysplastic progression of the gastric type. Virchows Arch. 1999; 435; 452-457.
Mannan A, Vieth M, Khararjian A et al. The outlet patch: gastric heterotopia of the colorectum and anus. Histopathology 2018; 73; 220-229.
Kushima R, Remmele W, Stolte M, Borchard F. Pyloric gland type adenoma of the gallbladder with squamoid spindle cell metaplasia. Pathol. Res. Pract. 1996; 192; 963-969; discussion 70-71.
Choi WT, Brown I, Ushiku T et al. Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases. Histopathology 2018; 72; 1007-1014.
Hashimoto T, Ogawa R, Matsubara A et al. Familial adenomatous polyposis-associated and sporadic pyloric gland adenomas of the upper gastrointestinal tract share common genetic features. Histopathology 2015; 67; 689-698.
Lee SE, Kang SY, Cho J et al. Pyloric gland adenoma in Lynch syndrome. Am. J. Surg. Pathol. 2014; 38; 784-792.
Wood LD, Salaria SN, Cruise MW, Giardiello FM, Montgomery EA. Upper GI tract lesions in familial adenomatous polyposis (FAP): enrichment of pyloric gland adenomas and other gastric and duodenal neoplasms. Am. J. Surg. Pathol. 2014; 38; 389-393.
Ma C, Giardiello FM, Montgomery EA. Upper tract juvenile polyps in juvenile polyposis patients: dysplasia and malignancy are associated with foveolar, intestinal, and pyloric differentiation. Am. J. Surg. Pathol. 2014; 38; 1618-1626.
Hackeng WM, Montgomery EA, Giardiello FM et al. Morphology and genetics of pyloric gland adenomas in familial adenomatous polyposis. Histopathology 2017; 70; 549-557.
Kushima R, Müller W, Stolte M, Borchard F. Differential p53 protein expression in stomach adenomas of gastric and intestinal phenotypes: possible sequences of p53 alteration in stomach carcinogenesis. Virchows Arch. 1996; 428; 223-227.
Hirota WK, Zuckerman MJ, Adler DG et al. ASGE guideline: the role of endoscopy in the surveillance of premalignant conditions of the upper GI tract. Gastrointest. Endosc. 2006; 63; 570-580.
Tsukamoto T, Yokoi T, Maruta S et al. Gastric adenocarcinoma with chief cell differentiation. Pathol. Int. 2007; 57; 517-522.
Ushiku T, Kunita A, Kuroda R et al. Oxyntic gland neoplasm of the stomach: expanding the spectrum and proposal of terminology. Mod. Pathol. 2020; 33; 206-216.
Takahashi K, Fujiya M, Ichihara S, Moriichi K, Okumura T. Inverted gastric adenocarcinoma of fundic gland mucosa type colliding with well differentiated adenocarcinoma: a case report. Medicine 2017; 96; e7080.
Uchida A, Ozawa M, Ueda Y et al. Gastric adenocarcinoma of fundic gland mucosa type localized in the submucosa: a case report. Medicine 2018; 97; e12341.
Singhi AD, Lazenby AJ, Montgomery EA. Gastric adenocarcinoma with chief cell differentiation: a proposal for reclassification as oxyntic gland polyp/adenoma. Am. J. Surg. Pathol. 2012; 36; 1030-1035.
Ueyama H, Matsumoto K, Nagahara A, Hayashi T, Yao T, Watanabe S. Gastric adenocarcinoma of the fundic gland type (chief cell predominant type). Endoscopy 2014; 46; 153-157.
Hidaka Y, Mitomi H, Saito T et al. Alteration in the Wnt/β-catenin signaling pathway in gastric neoplasias of fundic gland (chief cell predominant) type. Hum. Pathol. 2013; 44; 2438-2448.
Nomura R, Saito T, Mitomi H et al. GNAS mutation as an alternative mechanism of activation of the Wnt/β-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type. Hum. Pathol. 2014; 45; 2488-2496.
Ueo T, Yonemasu H, Ishida T. Gastric adenocarcinoma of fundic gland type with unusual behavior. Dig. Endosc. 2014; 26; 293-294.
Kato M, Uraoka T, Isobe Y et al. A case of gastric adenocarcinoma of fundic gland type resected by combination of laparoscopic and endoscopic approaches to neoplasia with non-exposure technique (CLEAN-NET). Clin. J. Gastroenterol. 2015; 8; 393-399.
Jung SH, Chung WC, Kim EJ et al. Evaluation of non-ampullary duodenal polyps: comparison of non-neoplastic and neoplastic lesions. World J. Gastroenterol. 2010; 16; 5474-5480.
Rosty C, Campbell C, Clendenning M, Bettington M, Buchanan DD, Brown IS. Do serrated neoplasms of the small intestine represent a distinct entity? Pathological findings and molecular alterations in a series of 13 cases. Histopathology 2015; 66; 333-342.
Kiremitçi S, Cansız Ersöz C, Savaş B, Ensari A. Gastric and small intestinal traditional serrated adenomas: a detailed morphologic and immunohistochemical analysis. Turkish J. Gastroenterol. 2020; 31; 441-450.
Mitsuishi T, Hamatani S, Hirooka S et al. Clinicopathological characteristics of duodenal epithelial neoplasms: focus on tumors with a gastric mucin phenotype (pyloric gland-type tumors). PLoS One 2017; 12; e0174985.
Hijikata K, Nemoto T, Igarashi Y, Shibuya K. Extra-ampullary duodenal adenoma: a clinicopathological study. Histopathology 2017; 71; 200-207.
Terada T. Pathologic observations of the duodenum in 615 consecutive duodenal specimens: I. Benign lesions. Int. J. Clin. Exp. Pathol. 2012; 5; 46-51.
Fujisawa T, Horimatsu T, Sakaguchi K et al. Duodenal adenoma of gastric foveolar phenotype in the second portion of the duodenum. Dig. Endosc. 2006; 18; 62-66.
Kim K, Jang SJ, Song HJ, Yu E. Clinicopathologic characteristics and mucin expression in Brunner's gland proliferating lesions. Dig. Dis. Sci. 2013; 58; 194-201.
Wood LD, Noë M, Hackeng W et al. Patients with McCune-Albright syndrome have a broad spectrum of abnormalities in the gastrointestinal tract and pancreas. Virchows Arch. 2017; 470; 391-400.
Matsubara A, Ogawa R, Suzuki H et al. Activating GNAS and KRAS mutations in gastric foveolar metaplasia, gastric heterotopia, and adenocarcinoma of the duodenum. Br. J. Cancer 2015; 112; 1398-1404.
Miller GC, Kumarasinghe MP, Borowsky J et al. Clinicopathological features of pyloric gland adenomas of the duodenum: a multicentre study of 57 cases. Histopathology 2020; 76; 404-410.
Dawson IM, Pryse-Davies J. The development of carcinoma of the large intestine in ulcerative colitis. Br. J. Surg. 1959; 47; 113-128.
Andersen SN, Lovig T, Clausen OP, Bakka A, Fausa O, Rognum TO. Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-ras mutations. Gut 1999; 45; 686-692.
Rubio CA, Johansson C, Slezak P, Ohman U, Hammarberg C. Villous dysplasia. An ominous histologic sign in colitic patients. Dis. Colon Rectum 1984; 27; 283-287.
Rubio CA, Nylander G, Johansson C, Slezak P. Non-dysplastic villous changes in endoscopic biopsies in ulcerative colitis with carcinoma. Acta Pathol. Microbiol. Immunol. Scand. A Pathol. 1982; 90; 277-282.
Choi WT, Yozu M, Miller GC et al. Nonconventional dysplasia in patients with inflammatory bowel disease and colorectal carcinoma: a multicenter clinicopathologic study. Mod. Pathol. 2020; 33; 933-943.
Lee H, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT. DNA flow cytometric and clinicopathologic analysis of non-conventional dysplasia and serrated lesions in inflammatory bowel disease. Mod. Pathol. 2020; 33(suppl. 2); 702A.
Rubio CA, Befrits R, Jaramillo E, Nesi G, Amorosi A. Villous and serrated adenomatous growth bordering carcinomas in inflammatory bowel disease. Anticancer Res. 2000; 20; 4761-4764.
Rubio CA. Serrated neoplasias and de novo carcinomas in ulcerative colitis: a histological study in colectomy specimens. J. Gastroenterol. Hepatol. 2007; 22; 1024-1031.
Harpaz N, Goldblum JR, Shepherd N et al. Novel classification of dysplasia in IBD. Mod. Pathol. 2017; 30(Suppl. 2); 174A.
Bettington ML, Walker NI, Rosty C et al. A clinicopathological and molecular analysis of 200 traditional serrated adenomas. Mod. Pathol. 2015; 28; 414-427.
Ko HM, Harpaz N, McBride RB et al. Serrated colorectal polyps in inflammatory bowel disease. Mod. Pathol. 2015; 28; 1584-1593.
Lee LH, Iacucci M, Fort Gasia M, Ghosh S, Panaccione R, Urbanski S. Prevalence and anatomic distribution of serrated and adenomatous lesions in patients with inflammatory bowel disease. Can. J. Gastroenterol. Hepatol. 2017; 2017; 5490803.
Choi WT, Wen KW, Rabinovitch PS, Huang D, Mattis AN, Gill RM. DNA content analysis of colorectal serrated lesions detects an aneuploid subset of inflammatory bowel disease-associated serrated epithelial change and traditional serrated adenomas. Histopathology 2018; 73; 464-472.
Yang C, Tarabishy Y, Dassopoulos T, Nalbantoglu I. Clinical, histologic, and immunophenotypic features of serrated polyps in patients with inflammatory bowel disease. Gastroenterol. Res. 2018; 11; 355-360.
Patil DT, Goldblum JR, Odze RD. Immunohistochemical and molecular characterization of dysplasia subtypes in ulcerative colitis. Mod Pathol. 2017; 30(suppl. 2); 194A.
Wen KW, Umetsu SE, Goldblum JR et al. DNA flow cytometric and interobserver study of crypt cell atypia in inflammatory bowel disease. Histopathology 2019; 75; 578-588.