Regulation of Lipid Bilayer Ion Permeability by Antibacterial Polymethyloxazoline-Polyethyleneimine Copolymers.
amphiphilic copolymers
antibacterial agents
bilayer lipid membranes
ion channels
membrane permeabilization
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
16 03 2021
16 03 2021
Historique:
revised:
28
10
2020
received:
18
09
2020
pubmed:
31
10
2020
medline:
20
11
2021
entrez:
30
10
2020
Statut:
ppublish
Résumé
Amphiphilic antimicrobial polymers display activity against the outer bacterial cell membrane, triggering various physiological effects. We investigated the regulation of ion transport across the lipid bilayer to understand differences in biological activity for a series of amphiphilic polymethyloxazoline - polyethyleneimine copolymers. The results confirmed that the tested structures were able to increase the permeability of the lipid bilayer (LB) membrane or its rupture. Black lipid membrane (BLM) experiments show that the triggered conductance profile and its character is strongly correlated with the polymer structure and zeta potential. The polymer exhibiting the highest antimicrobial activity promotes ion transport by using a unique mechanism and step-like characteristics with well-defined discreet openings and closings. The molecule was incorporated into the membrane in a reproducible way, and the observed channel-like activity could be responsible for the antibacterial activity of this molecule.
Identifiants
pubmed: 33124737
doi: 10.1002/cbic.202000656
doi:
Substances chimiques
Anti-Bacterial Agents
0
Ions
0
Lipid Bilayers
0
Polymers
0
Polyethyleneimine
9002-98-6
Magnesium
I38ZP9992A
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1020-1029Subventions
Organisme : National Science Center
Organisme : PoCoDi
ID : 2015/18/E/ST5/00222
Organisme : Nencki Institute of Experimental Biology
Informations de copyright
© 2020 Wiley-VCH GmbH.
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