Programmed death ligand-1 induction restrains the cytotoxic T lymphocyte response against microglia.

Animals B7-H1 Antigen CD8-Positive T-Lymphocytes Immune Checkpoint Inhibitors Mice Mice, Inbred BALB C Mice, Inbred C57BL Microglia Peptides / pharmacology Programmed Cell Death 1 Receptor T-Lymphocytes, Cytotoxic
HIV-associated neurocognitive disorders brain-resident memory T-cells cytotoxic T lymphocyte microglia programmed death (PD)-1: PD-L1 pathway

Journal

Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785

Informations de publication

Date de publication:
04 2021
Historique:
received: 18 02 2020
revised: 15 10 2020
accepted: 18 10 2020
pubmed: 1 11 2020
medline: 8 2 2022
entrez: 31 10 2020
Statut: ppublish

Résumé

Microglial cells are the main reservoir for HIV-1 within the brain and potential exists for negative immune checkpoint blockade therapies to purge this viral reservoir. Here, we investigated cytolytic responses of CD8

Identifiants

DOI: 10.1002/glia.23932 PMID: 33128485 PMC: PMC8549117
pubmed: 33128485
doi: 10.1002/glia.23932
pmc: PMC8549117
mid: NIHMS1748702
doi:

Substances chimiques

B7-H1 Antigen 0
Immune Checkpoint Inhibitors 0
Peptides 0
Programmed Cell Death 1 Receptor 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

858-871

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH066703
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS038836
Pays : United States

Informations de copyright

© 2020 Wiley Periodicals LLC.

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Auteurs

Priyanka Chauhan (P)

Neurovirology Laboratory, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Shuxian Hu (S)

Neurovirology Laboratory, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Sujata Prasad (S)

Neurovirology Laboratory, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Wen S Sheng (WS)

Neurovirology Laboratory, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

James R Lokensgard (JR)

Neurovirology Laboratory, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
ORCID: 0000-0002-1976-2035

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Programmed death ligand-1 induction restrains...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › Programmed death ligand-1 induction restrains...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Programmed death ligand-1 induction restrains...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Inhibiteurs de points de contrôle immunitaires › Programmed death ligand-1 induction restrains...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Programmed death ligand-1 induction restrains...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Programmed death ligand-1 induction restrains...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Programmed death ligand-1 induction restrains...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Programmed death ligand-1 induction restrains...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Programmed death ligand-1 induction restrains...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Récepteur-1 de mort cellulaire programmée › Programmed death ligand-1 induction restrains...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T cytotoxiques › Programmed death ligand-1 induction restrains...