Long period grating in double cladding fiber coated with graphene oxide as high-performance optical platform for biosensing.
C-Reactive protein
Double cladding fiber sensors
Graphene oxide
Label-free biosensors
Long period gratings
Real-time biomolecule detection
Journal
Biosensors & bioelectronics
ISSN: 1873-4235
Titre abrégé: Biosens Bioelectron
Pays: England
ID NLM: 9001289
Informations de publication
Date de publication:
15 Jan 2021
15 Jan 2021
Historique:
received:
21
05
2020
revised:
11
10
2020
accepted:
18
10
2020
pubmed:
1
11
2020
medline:
15
5
2021
entrez:
31
10
2020
Statut:
ppublish
Résumé
In this work, the development and testing of a novel fiber-optic based label-free biosensor is presented, whose performance were verified through the detection of C-reactive protein (CRP) in serum. The device is based on a long period grating fabricated in a double cladding fiber with a W-shaped refractive index (RI) profile. As a result, the working point of the device was tuned to the mode transition region by chemical etching of the outer fiber cladding, obtaining a significant enhancement of the RI sensitivity and an excellent visibility of the grating resonances due to the mode transition in an all-silica structure. The fiber transducer was coated with a nanometric thin layer of graphene oxide in order to provide functional groups for the covalent immobilization of the biological recognition element. A very low limit of detection of about 0.15 ng/mL was obtained during the detection of CRP in serum, and a large working range (1 ng/mL - 100 μg/mL) of clinical relevance has been also achieved.
Identifiants
pubmed: 33129073
pii: S0956-5663(20)30735-1
doi: 10.1016/j.bios.2020.112747
pmc: PMC7581380
pii:
doi:
Substances chimiques
graphene oxide
0
Graphite
7782-42-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112747Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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