Nucleotide P2Y
Adenosine A1 Receptor Agonists
/ pharmacokinetics
Adenosine A3 Receptor Agonists
/ pharmacokinetics
Adenosine Diphosphate
/ analogs & derivatives
Animals
Deoxyadenine Nucleotides
/ pharmacokinetics
Female
Humans
Mice
Mice, Inbred C57BL
Prodrugs
/ pharmacokinetics
Purinergic P2Y Receptor Agonists
/ pharmacokinetics
Purinergic P2Y Receptor Antagonists
/ pharmacokinetics
Receptor, Adenosine A1
/ metabolism
Receptor, Adenosine A3
/ metabolism
Receptors, Purinergic P2Y1
/ metabolism
A1 receptor
A3 receptor
Adenosine
Ectonucleotidase
P2Y1 receptor
Prodrug
Journal
Purinergic signalling
ISSN: 1573-9546
Titre abrégé: Purinergic Signal
Pays: Netherlands
ID NLM: 101250499
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
24
04
2020
accepted:
13
09
2020
pubmed:
1
11
2020
medline:
27
10
2021
entrez:
31
10
2020
Statut:
ppublish
Résumé
Rapid phosphoester hydrolysis of endogenous purine and pyrimidine nucleotides has challenged the characterization of the role of P2 receptors in physiology and pathology. Nucleotide phosphoester stabilization has been pursued on a number of medicinal chemistry fronts. We investigated the in vitro and in vivo stability and pharmacokinetics of prototypical nucleotide P2Y
Identifiants
pubmed: 33129204
doi: 10.1007/s11302-020-09732-z
pii: 10.1007/s11302-020-09732-z
pmc: PMC7855190
doi:
Substances chimiques
(N)-methanocarba-2MeSADP
0
2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate
0
Adenosine A1 Receptor Agonists
0
Adenosine A3 Receptor Agonists
0
Deoxyadenine Nucleotides
0
N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate
0
Prodrugs
0
Purinergic P2Y Receptor Agonists
0
Purinergic P2Y Receptor Antagonists
0
Receptor, Adenosine A1
0
Receptor, Adenosine A3
0
Receptors, Purinergic P2Y1
0
Adenosine Diphosphate
61D2G4IYVH
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
543-559Subventions
Organisme : NINDS NIH HHS
ID : R41NS0993756
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIADK31117
Pays : United States
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