Arming Yourself for The In Silico Protein Design Revolution.

Biotechnology / trends Computer Simulation Protein Engineering Proteins / genetics Research / trends
protein design synthetic biology

Journal

Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903

Informations de publication

Date de publication:
07 2021
Historique:
received: 07 04 2020
revised: 05 10 2020
accepted: 05 10 2020
pubmed: 4 11 2020
medline: 9 10 2021
entrez: 3 11 2020
Statut: ppublish

Résumé

Proteins mediate many essential processes of life to a degree of functional precision unmatched by any synthetic device. While engineered proteins are currently used in biotech, food, biomedicine, and material technology-based industries, the true potential of proteins is practically untapped. The emerging field of in silico protein design is predicted to provide the next quantum leap in the biotech industry. Having predictive control over protein function and the ability to redefine these functions have driven the field of protein engineering into an era of unprecedented development. This article provides a holistic analysis of protein design R&D (current state-of-the-art tools and knowhow) and commercial landscape, as well as a one-stop-shop profile of in silico protein design technology for biotechnology stakeholders.

Identifiants

DOI: 10.1016/j.tibtech.2020.10.003 PMID: 33139074
pubmed: 33139074
pii: S0167-7799(20)30267-5
doi: 10.1016/j.tibtech.2020.10.003
pii:
doi:

Substances chimiques

Proteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

651-664

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Sidney P Walker (SP)

CancerResearch@UCC, University College Cork, Cork, Ireland; SynBioCentre, University College Cork, Cork, Ireland.

Venkata V B Yallapragada (VVB)

CancerResearch@UCC, University College Cork, Cork, Ireland; SynBioCentre, University College Cork, Cork, Ireland.

Mark Tangney (M)

CancerResearch@UCC, University College Cork, Cork, Ireland; SynBioCentre, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland. Electronic address: m.tangney@ucc.ie.

Articles similaires

Exploring structural diversity across the protein universe with The Encyclopedia of Domains.

Andy M Lau, Nicola Bordin, Shaun M Kandathil et al.
1.00
Databases, Protein Protein Domains Protein Folding Proteins Deep Learning

A new estimator of between study variance of standardized mean difference in meta-analysis.

Ramlah H Albayyat, Hajar S Aljohani, Dalia K Alnagar
1.00
Humans Meta-Analysis as Topic Sample Size Models, Statistical Computer Simulation

An arithmetic operation P system based on symmetric ternary system.

Hai Nan, Jie Zhang, Ping Guo et al.
1.00
Humans Algorithms Software Artificial Intelligence Computer Simulation

Assessment of first-touch skills in robotic surgical training using hi-Sim and the hinotori surgical robot system among surgeons and novices.

Takeshi Urade, Nobuaki Yamasaki, Munenori Uemura et al.
1.00
Humans Robotic Surgical Procedures Clinical Competence Male Female

Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Biotechnologie › Arming Yourself for The In Silico Protein...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Arming Yourself for The In Silico Protein...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Arming Yourself for The In Silico Protein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Arming Yourself for The In Silico Protein...
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Arming Yourself for The In Silico Protein...