Validation of a new hand function outcome measure in individuals with Charcot-Marie-Tooth disease.
Adult
Aged
Aged, 80 and over
Charcot-Marie-Tooth Disease
/ diagnosis
Diagnostic Techniques, Neurological
/ standards
Female
Hand
/ physiopathology
Hand Strength
/ physiology
Humans
Male
Middle Aged
Motor Activity
/ physiology
Outcome Assessment, Health Care
/ standards
Pinch Strength
/ physiology
Reproducibility of Results
Young Adult
Charcot-Marie-Tooth
engineered glove
hand function
neuropathies
outcome measures
Journal
Journal of the peripheral nervous system : JPNS
ISSN: 1529-8027
Titre abrégé: J Peripher Nerv Syst
Pays: United States
ID NLM: 9704532
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
30
07
2020
revised:
23
10
2020
accepted:
26
10
2020
pubmed:
4
11
2020
medline:
28
9
2021
entrez:
3
11
2020
Statut:
ppublish
Résumé
The symptomatology of Charcot-Marie-Tooth (CMT) disease mainly involves the feet and the hands. To date, there is no consensus on how to evaluate hand function in CMT. The aim of this study is to correlate the data of the engineered glove Hand Test System (HTS) with specific tests and the CMT examination score (CMTES). We analyzed 45 patients with the diagnosis of CMT using HTS, which measures the hand dexterity by specific sequences performed at maximum velocity. We completed the evaluation with the CMTES, tripod pinch and hand grip strength tested by a dynamometer, thumb opposition test (TOT), and Sollerman Hand function test (SHFT), and we conducted a test-retest with 20 normal subjects. Finger tapping (FT) and index-medium-ring-little (IMRL) sequence showed a significant correlation with CMTES (FT: dominant hand (DH): P = .036; non-dominant hand (NDH): P = .033; IMRL: DH: P = .009; NDH: P = .046). TOT correlated with CMTES significantly in both hands (P < .0001). tripod pinch showed a statistically significant correlation with CMTES (DH: P = .002; NDH: P = .005). Correlation between the hand grip and CMTES was significant only in DH (DH: P = .002). SHFT had a significant correlation with the CMTES (DH: P = .002). Test-retest showed a good reliability. HTS parameters correlate with CMTES confirming that this tool is sensitive to the hand deficits. In conclusion, we can state that HTS is a good, simple to use, and objective instrument to evaluate the hand function of CMT patients, but more studies on responsiveness and sensitivity are needed.
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
413-422Informations de copyright
© 2020 Peripheral Nerve Society.
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