A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities.
Adipocytes
/ cytology
Animals
Binding Sites
Cell Differentiation
/ drug effects
Cell Line
Glucose
/ metabolism
Hepatocytes
/ cytology
Humans
Kinetics
Lipid Metabolism
/ drug effects
Molecular Docking Simulation
PPAR alpha
/ agonists
PPAR gamma
/ agonists
Phosphorylation
/ drug effects
Protein Binding
Rats
Transcriptional Activation
/ drug effects
Valine
/ analogs & derivatives
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
12 11 2020
12 11 2020
Historique:
pubmed:
4
11
2020
medline:
19
12
2020
entrez:
3
11
2020
Statut:
ppublish
Résumé
A proprietary library of novel
Identifiants
pubmed: 33142057
doi: 10.1021/acs.jmedchem.0c01555
pmc: PMC10211484
mid: NIHMS1901628
doi:
Substances chimiques
PPAR alpha
0
PPAR gamma
0
Valine
HG18B9YRS7
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13124-13139Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK071900
Pays : United States
Références
Sci Rep. 2015 Apr 01;5:9530
pubmed: 25827822
Eur J Gastroenterol Hepatol. 2017 Dec;29(12):1385-1388
pubmed: 29023319
Cell. 2012 Jul 20;150(2):366-76
pubmed: 22796012
Cell Mol Life Sci. 2018 Aug;75(16):2951-2961
pubmed: 29789866
Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):79-94
pubmed: 24933330
Curr Mol Pharmacol. 2019;12(3):195-201
pubmed: 30636619
Am J Cardiol. 2007 Mar 19;99(6A):3C-18C
pubmed: 17368275
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702
Adipocyte. 2014 Dec 10;3(4):314-21
pubmed: 26317056
Mol Cell Biol. 2009 Sep;29(17):4714-28
pubmed: 19564408
Genes Dev. 2013 Feb 1;27(3):234-50
pubmed: 23388824
J Hepatol. 2015 Mar;62(3):720-33
pubmed: 25450203
Int J Mol Sci. 2018 Apr 14;19(4):
pubmed: 29662003
Atherosclerosis. 2016 Apr;247:35-39
pubmed: 26854974
Cardiovasc Hematol Agents Med Chem. 2012 Jun;10(2):124-34
pubmed: 22471957
Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2563-E2570
pubmed: 28320959
Cell Metab. 2005 Jun;1(6):361-70
pubmed: 16054085
ACS Chem Biol. 2016 Jan 15;11(1):273-83
pubmed: 26579553
Endocr Metab Immune Disord Drug Targets. 2006 Mar;6(1):33-43
pubmed: 16611163
J Comput Aided Mol Des. 2011 Aug;25(8):717-28
pubmed: 21691811
Toxicol Appl Pharmacol. 2009 Nov 1;240(3):348-54
pubmed: 19632256
Expert Opin Drug Saf. 2012 Jul;11(4):565-79
pubmed: 22616948
Am J Clin Nutr. 2010 Jan;91(1):267S-272S
pubmed: 19906796
Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21
pubmed: 9757107
Int J Mol Sci. 2018 Oct 26;19(11):
pubmed: 30373124
J Cell Physiol. 2018 Jan;233(1):153-161
pubmed: 28098353
Biochimie. 2012 Dec;94(12):2569-76
pubmed: 22835478
Endocrinology. 1996 Jan;137(1):354-66
pubmed: 8536636
Nature. 2010 Jul 22;466(7305):451-6
pubmed: 20651683
Curr Opin Pharmacol. 2006 Dec;6(6):606-14
pubmed: 16973418
Mol Endocrinol. 2000 Sep;14(9):1425-33
pubmed: 10976920
Front Endocrinol (Lausanne). 2011 Nov 29;2:87
pubmed: 22654831
J Med Chem. 2020 May 14;63(9):4811-4823
pubmed: 32239932
Diabetes Technol Ther. 2014 Feb;16(2):63-71
pubmed: 24138536
ACS Med Chem Lett. 2019 Feb 25;10(4):545-551
pubmed: 30996794
Clin Drug Investig. 2019 Jun;39(6):553-563
pubmed: 31037611
Nature. 2011 Sep 04;477(7365):477-81
pubmed: 21892191
J Biol Chem. 2007 Jun 8;282(23):17314-24
pubmed: 17403688
J Clin Invest. 2000 Aug;106(4):467-72
pubmed: 10953021
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
Mol Divers. 2006 Aug;10(3):349-60
pubmed: 17031537
Stem Cells. 2009 Nov;27(11):2753-60
pubmed: 19697348
Anal Biochem. 2005 Sep 1;344(1):8-15
pubmed: 16038868
Int J Mol Sci. 2018 Oct 04;19(10):
pubmed: 30287791
J Med Chem. 2018 Sep 27;61(18):8282-8298
pubmed: 30199253
Cardiovasc Diabetol. 2019 Mar 21;18(1):38
pubmed: 30898163
Cell Metab. 2012 Mar 7;15(3):395-404
pubmed: 22405074
J Diabetes Sci Technol. 2014 Jan 16;8(1):132-141
pubmed: 24876549