Glucocorticoid-dependent transcription in skin requires epidermal expression of the glucocorticoid receptor and is modulated by the mineralocorticoid receptor.
Animals
Cell Line
Computational Biology
Epidermis
/ drug effects
Female
Fibroblasts
/ drug effects
Glucocorticoids
/ pharmacology
Immunoblotting
Mice
Receptors, Glucocorticoid
/ genetics
Receptors, Mineralocorticoid
/ genetics
Reverse Transcriptase Polymerase Chain Reaction
Skin
/ drug effects
Skin Diseases
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 11 2020
03 11 2020
Historique:
received:
06
08
2020
accepted:
05
10
2020
entrez:
4
11
2020
pubmed:
5
11
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Glucocorticoid (GC) actions are mediated through two closely related ligand-dependent transcription factors, the GC receptor (GR) and the mineralocorticoid receptor (MR). Given the wide and effective use of GCs to combat skin inflammatory diseases, it is important to understand the relative contribution of these receptors to the transcriptional response to topical GCs. We evaluated the gene expression profiles in the skin of mice with epidermal-specific loss of GR (GR
Identifiants
pubmed: 33144612
doi: 10.1038/s41598-020-75853-5
pii: 10.1038/s41598-020-75853-5
pmc: PMC7609727
doi:
Substances chimiques
Glucocorticoids
0
Receptors, Glucocorticoid
0
Receptors, Mineralocorticoid
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18954Références
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