Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation.
A549 Cells
Adolescent
Adult
Animals
Antigens
/ metabolism
Bordetella
/ physiology
Child
Colony Count, Microbial
Disease Models, Animal
Host Microbial Interactions
/ genetics
Humans
Hypersensitivity
/ complications
Immunity
Inflammation
/ complications
Lung
/ immunology
Mice, Inbred C57BL
Microbiota
Ovalbumin
/ immunology
Secretory Leukocyte Peptidase Inhibitor
/ metabolism
Th17 Cells
/ immunology
Transcriptome
/ genetics
Young Adult
Bordetella pseudohinzii
Haemophilus
T helper 17 (Th17)
airway microbiome
airway microbiota
allergic airway inflammation
antimicrobial peptide
asthma
interleukin-17 (IL-17)
secretory leukocyte protease inhibitor (SLPI)
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
03 11 2020
03 11 2020
Historique:
received:
21
02
2020
revised:
22
08
2020
accepted:
08
10
2020
entrez:
4
11
2020
pubmed:
5
11
2020
medline:
8
5
2021
Statut:
ppublish
Résumé
Homeostatic mucosal immune responses are fine-tuned by naturally evolved interactions with native microbes, and integrating these relationships into experimental models can provide new insights into human diseases. Here, we leverage a murine-adapted airway microbe, Bordetella pseudohinzii (Bph), to investigate how chronic colonization impacts mucosal immunity and the development of allergic airway inflammation (AAI). Colonization with Bph induces the differentiation of interleukin-17A (IL-17A)-secreting T-helper cells that aid in controlling bacterial abundance. Bph colonization protects from AAI and is associated with increased production of secretory leukocyte protease inhibitor (SLPI), an antimicrobial peptide with anti-inflammatory properties. These findings are additionally supported by clinical data showing that higher levels of upper respiratory SLPI correlate both with greater asthma control and the presence of Haemophilus, a bacterial genus associated with AAI. We propose that SLPI could be used as a biomarker of beneficial host-commensal relationships in the airway.
Identifiants
pubmed: 33147448
pii: S2211-1247(20)31320-6
doi: 10.1016/j.celrep.2020.108331
pmc: PMC7685510
mid: NIHMS1643871
pii:
doi:
Substances chimiques
Antigens
0
Secretory Leukocyte Peptidase Inhibitor
0
Ovalbumin
9006-59-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108331Subventions
Organisme : NIAID NIH HHS
ID : K08 AI113184
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136515
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007200
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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