Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody.
Aquapotin-4
Attacks
Myelin-oligodendrocyte glycoprotein
Neuromyelitis optica spectrum disorders
Seasonal distribution
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
received:
06
10
2020
revised:
24
10
2020
accepted:
26
10
2020
pubmed:
5
11
2020
medline:
17
12
2020
entrez:
4
11
2020
Statut:
ppublish
Résumé
This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) showed spring-summer predominance of the clinical onset. Conversely, patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease showed autumn-winter predominance of the clinical onset. Both seasonal variations were irrespective of the clinical manifestation. Environmental factors with seasonal variation influence the development of neurological conditions related to AQP4-IgG and MOG-IgG.
Identifiants
pubmed: 33147540
pii: S0165-5728(20)30692-5
doi: 10.1016/j.jneuroim.2020.577431
pii:
doi:
Substances chimiques
AQP4 protein, human
0
Aquaporin 4
0
Autoantibodies
0
MOG protein, human
0
Myelin-Oligodendrocyte Glycoprotein
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
577431Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.