Changes in subcellular structures and states of pumilio 1 regulate the translation of target
Meiosis
Oocyte
Pumilio 1
Translational control
Vertebrate
mRNA localization
Journal
Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457
Informations de publication
Date de publication:
11 12 2020
11 12 2020
Historique:
received:
19
05
2020
accepted:
22
10
2020
pubmed:
6
11
2020
medline:
22
6
2021
entrez:
5
11
2020
Statut:
epublish
Résumé
Temporal and spatial control of mRNA translation has emerged as a major mechanism for promoting diverse biological processes. However, the molecular nature of temporal and spatial control of translation remains unclear. In oocytes, many mRNAs are deposited as a translationally repressed form and are translated at appropriate times to promote the progression of meiosis and development. Here, we show that changes in subcellular structures and states of the RNA-binding protein pumilio 1 (Pum1) regulate the translation of target mRNAs and progression of oocyte maturation. Pum1 was shown to bind to
Identifiants
pubmed: 33148609
pii: jcs.249128
doi: 10.1242/jcs.249128
pii:
doi:
Substances chimiques
Ccnb1 protein, mouse
0
Cyclin B1
0
Mad2 Proteins
0
Mad2l1 protein, mouse
0
RNA, Messenger
0
RNA-Binding Proteins
0
pumilio 1 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.