Structural duality enables a single protein to act as a toxin-antidote pair for meiotic drive.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
05 Nov 2024
Historique:
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 1 11 2024
Statut: ppublish

Résumé

In sexual reproduction, selfish genetic elements known as killer meiotic drivers (KMDs) bias inheritance by eliminating gametes that do not carry them. The selective killing behavior of most KMDs can be explained by a toxin-antidote model, where a toxin harms all gametes while an antidote provides resistance to the toxin in carriers. This study investigates whether and how the KMD element

Identifiants

pubmed: 39485800
doi: 10.1073/pnas.2408618121
doi:

Substances chimiques

Schizosaccharomyces pombe Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2408618121

Subventions

Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 31900405
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 91940302
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 91540201
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 31430024
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 31325007
Organisme : MOST | National Key Research and Development Program of China (NKPs)
ID : 2017YFA0504600

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Yu Hua (Y)

National Institute of Biological Sciences, Beijing 102206, China.

Jianxiu Zhang (J)

Key Laboratory of RNA Science and Engineering, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.

Man-Yun Yang (MY)

National Institute of Biological Sciences, Beijing 102206, China.

Jing-Yi Ren (JY)

National Institute of Biological Sciences, Beijing 102206, China.

Fang Suo (F)

National Institute of Biological Sciences, Beijing 102206, China.

Lingfei Liang (L)

Key Laboratory of RNA Science and Engineering, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.

Meng-Qiu Dong (MQ)

National Institute of Biological Sciences, Beijing 102206, China.
Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.

Keqiong Ye (K)

Key Laboratory of RNA Science and Engineering, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.

Li-Lin Du (LL)

National Institute of Biological Sciences, Beijing 102206, China.
Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.

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