A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring.

Schizosaccharomyces / genetics Meiosis / genetics Schizosaccharomyces pombe Proteins / metabolism Mitosis / genetics Epigenesis, Genetic Haplotypes
chromosome segregation cryo-EM structure epigenetic reader killer meiotic driver resistant haplotype

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
05 Nov 2024
Historique:
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 1 11 2024
Statut: ppublish

Résumé

Killer meiotic drivers (KMDs) are selfish genetic elements that distort Mendelian inheritance by selectively killing meiotic products lacking the KMD element, thereby promoting their own propagation. Although KMDs have been found in diverse eukaryotes, only a limited number of them have been characterized at the molecular level, and their killing mechanisms remain largely unknown. In this study, we identify that a gene previously deemed essential for cell survival in the fission yeast

Identifiants

DOI: 10.1073/pnas.2408347121 PMID: 39485795
pubmed: 39485795
doi: 10.1073/pnas.2408347121
doi:

Substances chimiques

Schizosaccharomyces pombe Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2408347121

Subventions

Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 31900405
Organisme : MOST | National Key Research and Development Program of China (NKPs)
ID : 2017YFA0504600

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Yu Hua (Y)

National Institute of Biological Sciences, Beijing 102206, China.

Jianxiu Zhang (J)

Key Laboratory of RNA Science and Engineering, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
ORCID: 0000-0002-1864-7510

Man-Yun Yang (MY)

National Institute of Biological Sciences, Beijing 102206, China.

Fan-Yi Zhang (FY)

National Institute of Biological Sciences, Beijing 102206, China.
Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.

Jing-Yi Ren (JY)

National Institute of Biological Sciences, Beijing 102206, China.

Xiao-Hui Lyu (XH)

National Institute of Biological Sciences, Beijing 102206, China.
ORCID: 0009-0007-4684-5710

Yan Ding (Y)

National Institute of Biological Sciences, Beijing 102206, China.

Fang Suo (F)

National Institute of Biological Sciences, Beijing 102206, China.
ORCID: 0000-0001-6526-5489

Guang-Can Shao (GC)

National Institute of Biological Sciences, Beijing 102206, China.

Jun Li (J)

National Institute of Biological Sciences, Beijing 102206, China.

Meng-Qiu Dong (MQ)

National Institute of Biological Sciences, Beijing 102206, China.
Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.
ORCID: 0000-0002-6094-1182

Keqiong Ye (K)

Key Laboratory of RNA Science and Engineering, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
ORCID: 0000-0001-6169-7049

Li-Lin Du (LL)

National Institute of Biological Sciences, Beijing 102206, China.
Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.
ORCID: 0000-0002-1028-7397

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Champignons › Levures › Schizosaccharomyces › A meiotic driver hijacks an epigenetic reader...
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Méiose › A meiotic driver hijacks an epigenetic reader...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Schizosaccharomyces pombe › A meiotic driver hijacks an epigenetic reader...
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Mitose › A meiotic driver hijacks an epigenetic reader...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › A meiotic driver hijacks an epigenetic reader...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Haplotypes › A meiotic driver hijacks an epigenetic reader...