Time-course of the visual Impact on presbyopes of a low dose miotic.
Accommodation, Ocular
/ drug effects
Adrenergic alpha-2 Receptor Agonists
/ administration & dosage
Adult
Brimonidine Tartrate
/ administration & dosage
Female
Humans
Intraocular Pressure
/ drug effects
Male
Middle Aged
Presbyopia
/ physiopathology
Pupil
/ drug effects
Reading
Refraction, Ocular
/ drug effects
Time Factors
Visual Acuity
/ drug effects
miotic
presbyopia
pupil
reading
visual acuity
Journal
Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
ISSN: 1475-1313
Titre abrégé: Ophthalmic Physiol Opt
Pays: England
ID NLM: 8208839
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
19
07
2020
revised:
05
09
2020
accepted:
06
09
2020
pubmed:
6
11
2020
medline:
23
11
2021
entrez:
5
11
2020
Statut:
ppublish
Résumé
To examine the pupil and visual impact of a single early morning drop of a low concentration miotic. Pupil size, refraction, visual acuity (VA), near reading performance and intraocular pressure were monitored for 8 h at a wide range of light levels following bilateral instillation of single drops of 0.1% brimonidine tartate in 19 early presbyopes (40-50 years) and 11 mature presbyopes (>50 years). Pupil miosis did not alter distance VA or refraction. Significant pupil miosis peaked at 1-2 h after dosing, which expanded the depth of focus of mature presbyopes with the mean improvement in near logMAR VA of -0.15, -0.07 and -0.03, at 20, 200 and 2000 lux, respectively. One hour after instillation, near reading speed improved by 21, 24 and 5 words per min for text size commonly seen in US newspaper and cellphone text messages, 18, 21 and 19 words per min for text size of grocery labels and 12, 13 and 30 words per min for text size of over-the-counter medications at light levels of 20, 200 and 2000 lux, respectively. No such improvements in near VA and near reading speed were observed in the young presbyopes having some residual accommodation. Most of the pupil miosis remained 8 h after instillation, whereas near VA improvements disappeared after 4 h. Low dose miotics can enhance near vision in presbyopic subjects while retaining high quality distance vision over a wide range of light levels. Significant improvements in near vision were observed only during the 1-2 h period after dosing when miosis peaked.
Substances chimiques
Adrenergic alpha-2 Receptor Agonists
0
Brimonidine Tartrate
4S9CL2DY2H
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-83Informations de copyright
© 2020 The Authors Ophthalmic and Physiological Optics © 2020 The College of Optometrists.
Références
Hickenbotham A, Tiruveedhula P & Roorda A. Comparison of spherical aberration and small-pupil profiles in improving depth of focus for presbyopic corrections. J Cataract Refract Surg 2012; 38(12): 2071-2079.
Seyeddain O, Hohensinn M, Riha W et al. Small-aperture corneal inlay for the correction of presbyopia: 3-year follow-up. J Cataract Refract Surg 2012; 38(1): 35-45.
Xu R, Thibos L & Bradley A. Effect of target luminance on optimum pupil diameter for presbyopic eyes. Optom Vis Sci 2016; 93(11): 1409-1419.
Dexl AK, Seyeddain O, Riha W et al. Reading performance and patient satisfaction after corneal inlay implantation for presbyopia correction: two-year follow-up. J Cataract Refract Surg 2012; 38(10): 1808-1816.
Xu R, Kollbaum P, Thibos L, Lopez-Gil N & Bradley A. Reducing starbursts in highly aberrated eyes with pupil miosis. Ophthalmic Physiol Opt 2018; 38(1): 26-36.
Atchison DA, Smith G & Efron N. The effect of pupil size on visual acuity in uncorrected and corrected myopia. Am J Optom Physiol Opt 1979; 56(5): 315-323.
Campbell FW & Gregory AH. Effect of size of pupil on visual acuity. Nature 1960; 187: 1121-1123.
McDonald JE 2nd, El-Moatassem Kotb AM & Decker BB. Effect of brimonidine tartrate ophthalmic solution 0.2% on pupil size in normal eyes under different luminance conditions. J Cataract Refract Surg 2001; 27(4): 560-564.
Drummond PD. The effect of light intensity and dose of dilute pilocarpine eyedrops on pupillary constriction in healthy subjects. Am J Ophthalmol 1991; 112(2): 195-199.
Serle JB. A comparison of the safety and efficacy of twice daily brimonidine 0.2% versus betaxolol 0.25% in subjects with elevated intraocular pressure. The Brimonidine Study Group III. Surv Ophthalmol 1996; 41(Suppl 1): S39-S47.
Hung PT, Hsieh JW & Chiou GC. Ocular hypotensive effects of N-demethylated carbachol on open angle glaucoma. Arch Ophthalmol 1982; 100(2): 262-264.
Brown SM, Khanani AM & McCartney DL. The effect of daily use of brimonidine tartrate on the dark-adapted pupil diameter. Am J Ophthalmol 2004; 138(1): 149-151.
Everett DE & Avorn J. Systemic effects of medications used to treat glaucoma. Ann Intern Med 1990; 112: 120-125.
Tsumura T, Yoshikawa K, Kimura T et al. The efficacy and safety of add-on 0.1% brimonidine tartrate preserved with sodium chlorite in on-treatment Japanese normal-tension glaucoma patients. Clin Ophthalmol 2014; 8: 1681-1687.
O'Brart DP, Lohmann CP, Fitzke FW, Smith SE, Kerr-Muir MG & Marshall J. Night vision after excimer laser photorefractive keratectomy: haze and halos. Eur J Ophthalmol 1994; 4(1): 43-51.
Abdelkader A. Improved presbyopic vision with miotics. Eye Contact Lens 2015; 41(5): 323-327.
Cantor LB. Brimonidine in the treatment of glaucoma and ocular hypertension. Ther Clin Risk Manag 2006; 2(4): 337-346.
Chateau N, De Brabander J, Bouchard F & Molenaar H. Infrared pupillometry in presbyopes fitted with soft contact lenses. Optom Vis Sci 1996; 73(12): 733-741.
Kardon RH, Kirkali PA & Thompson HS. Automated pupil perimetry. Pupil field mapping in patients and normal subjects. Ophthalmology 1991; 98(4): 485-496.
Moore DB, Beck J & Kryscio RJ. An objective assessment of the variability in number of drops per bottle of glaucoma medication. Bmc. Ophthalmology 2017; 17.
Drug USF. Alphagan P (Brimonidine Tartrate) Ophthalmic Solution. 2005; Available from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/021770s000TOC.cfm.
Legge GE, Pelli DG, Rubin GS & Schleske MM. Psychophysics of reading-I. Normal vision. Vision Res 1985; 25(2): 239-252.
Xu R & Bradley A. IURead: a new computer-based reading test. Ophthalmic Physiol Opt 2015; 35(5): 500-513.
Gamlin PD, McDougal DH, Pokorny J, Smith VC, Yau KW & Dacey DM. Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells. Vision Res 2007; 47(7): 946-954.
Liu CJ, Ko YC, Cheng CY et al. Changes in intraocular pressure and ocular perfusion pressure after latanoprost 0.005% or brimonidine tartrate 0.2% in normal-tension glaucoma patients. Ophthalmology 2002; 109(12): 2241-2247.
Gerente VM, Biondi AC, Barbosa CP, Lottenberg CL & Paranhos A Jr. Effect of brimonidine tartrate 0.15% on scotopic pupil: controlled trial. J Ocul Pharmacol Ther 2007; 23(5): 476-480.
Charman WN. Effect of refractive error in visual tests with sinusoidal gratings. Brit J Physiol Optics 1978; 33: 10-20.
Xu R, Wang H, Thibos LN & Bradley A. Interaction of aberrations, diffraction, and quantal fluctuations determine the impact of pupil size on visual quality. J Opt Soc Am A Opt Image Sci Vis 2017; 34(4): 481-492.
Tucker J & Charman WN. The depth-of-focus of the human eye for Snellen letters. Am J Optom Physiol Opt 1975; 52(1): 3-21.
Gruber N, Mosimann UP, Muri RM & Nef T. Vision and night driving abilities of elderly drivers. Traffic Inj Prev 2013; 14(5): 477-485.
Xu R, Gil D, Dibas M, Hare W & Bradley A. The effect of light level and small pupils on presbyopic reading performance. Invest Ophthalmol Vis Sci 2016; 57(13): 5656-5664.
Van Nes FL & Bouman MA. Spatial modulation transfer in the human eye. J Opt Soc Am 1967; 57: 401-406.
Banks MS, Geisler WS & Bennett PJ. The physical limits of grating visibility. Vision Res 1987; 27(11): 1915-1924.
Peli E, Apfelbaum H, Berson EL & Goldstein RB. The risk of pedestrian collisions with peripheral visual field loss. J Vis 2016;16(15):5.
Langenbucher A, Goebels S, Szentmary N, Seitz B & Eppig T. Vignetting and field of view with the KAMRA corneal inlay. Biomed Res Int 2013; 2013: 154593.
Atchison DA, Blazaki S, Suheimat M, Plainis S & Charman WN. Do small-aperture presbyopic corrections influence the visual field? Ophthalmic Physiol Opt 2016; 36(1): 51-59.
Bradley A, Nam J, Xu R, Harman L & Thibos L. Impact of contact lens zone geometry and ocular optics on bifocal retinal image quality. Ophthalmic Physiol Opt 2014; 34(3): 331-345.
Meister DJ & Fisher SW. Progress in the spectacle correction of presbyopia. Part 1: design and development of progressive lenses. Clin Exp Optom 2008;91(3):240-250.
Elliott DB. The Glenn A. Fry award lecture 2013: blurred vision, spectacle correction, and falls in older adults. Optom Vis Sci 2014;91(6):593-601.
Czajka A, Bowyer KW & Ortiz E. Analysis of diurnal changes in pupil dilation and eyelid aperture. IET Biometrics 2017; 7(2): 136-144.
DeMarco LM & Massof RW. Distributions of Print Sizes in U.S. Newspapers. J Vis Impair Blind 1997; 91(1): 1-9.
Legge GE & Bigelow CA. Does print size matter for reading? A review of findings from vision science and typography. J Vis 2011; 11(5): 8.
Bababekova Y, Rosenfield M, Hue JE & Huang RR. Font size and viewing distance of handheld smart phones. Optom Vis Sci. 2011; 88(7): 795-797.
Xu R, Chelales E, Rickert M et al. Small text on product labels poses a special challenge for emerging presbyopes. Optom Vis Sci. 2019; 96(4): 291-300.