Polyethylene oxide matrix tablet swelling evolution: The impact of molecular mass and tablet composition.
MRI
SAXS
WAXS
percolation threshold
polyethylene oxide
Journal
Acta pharmaceutica (Zagreb, Croatia)
ISSN: 1846-9558
Titre abrégé: Acta Pharm
Pays: Poland
ID NLM: 9303678
Informations de publication
Date de publication:
01 Jun 2021
01 Jun 2021
Historique:
accepted:
06
06
2020
entrez:
5
11
2020
pubmed:
6
11
2020
medline:
31
7
2021
Statut:
ppublish
Résumé
This article describes the designing of matrix tablets composed of polyethylene oxides (PEOs) with relative molecular masses of 1 × 106, 2 × 106, and 4 × 106. Percolation thresholds were determined for all of the selected PEO formulations (18, 16, and 12 %, m/m), taking into consideration excipients and tablet surface area which significantly increased the percolation threshold. Moreover, the robustness of the gel layer in PEO matrix tablets was evaluated by magnetic resonance imaging under various mechanical stresses (no flow, 12 mL min-1, and 64 mL-1 of medium flow). Correlations between the percolation threshold and gel thickness (R2 = 0.86), gel thickness and the erosion coefficient (R2 = 0.96) was detected. Furthermore, small-angle X-ray scattering of the selected PEOs detected differences in polymer molecular complexity at the nanoscale. Finally, the ratio of the heat of coalescence to the heat of fusion has confirmed the PEO molecular mass-dependent percolation threshold.
Identifiants
pubmed: 33151172
doi: 10.2478/acph-2021-0018
pii: acph-2021-0018
doi:
Substances chimiques
Excipients
0
Tablets
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
215-243Références
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