Prediction of Hospitalizations in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index.
Journal
Arthritis care & research
ISSN: 2151-4658
Titre abrégé: Arthritis Care Res (Hoboken)
Pays: United States
ID NLM: 101518086
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
22
10
2020
received:
17
12
2019
accepted:
03
11
2020
pubmed:
6
11
2020
medline:
6
5
2022
entrez:
5
11
2020
Statut:
ppublish
Résumé
The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) predicts mortality and damage accrual in systemic lupus erythematosus (SLE), but its association with hospitalizations has not been described. Our objective was to estimate the association of baseline SLICC-FI values with future hospitalizations in the SLICC inception cohort. Baseline SLICC-FI scores were calculated. The number and duration of inpatient hospitalizations during follow-up were recorded. Negative binomial regression was used to estimate the association between baseline SLICC-FI values and the rate of hospitalizations per patient-year of follow-up. Linear regression was used to estimate the association of baseline SLICC-FI scores with the proportion of follow-up time spent in the hospital. Multivariable models were adjusted for relevant baseline characteristics. The 1,549 patients with SLE eligible for this analysis were mostly female (88.7%), with a mean ± SD age of 35.7 ± 13.3 years and a median disease duration of 1.2 years (interquartile range 0.9-1.5) at baseline. Mean ± SD baseline SLICC-FI was 0.17 ± 0.08. During mean ± SD follow-up of 7.2 ± 3.7 years, 614 patients (39.6%) experienced 1,570 hospitalizations. Higher baseline SLICC-FI values (per 0.05 increment) were associated with more frequent hospitalizations during follow-up, with an incidence rate ratio of 1.21 (95% confidence interval [95% CI] 1.13-1.30) after adjustment for baseline age, sex, glucocorticoid use, immunosuppressive use, ethnicity/location, SLE Disease Activity Index 2000 score, SLICC/American College of Rheumatology Damage Index score, and disease duration. Among patients with ≥1 hospitalization, higher baseline SLICC-FI values predicted a greater proportion of follow-up time spent hospitalized (relative rate 1.09 [95% CI 1.02-1.16]). The SLICC-FI predicts future hospitalizations among incident SLE patients, further supporting the SLICC-FI as a valid health measure in SLE.
Identifiants
pubmed: 33152181
doi: 10.1002/acr.24504
pmc: PMC8096857
mid: NIHMS1644601
doi:
Substances chimiques
Immunosuppressive Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
638-647Subventions
Organisme : NCRR NIH HHS
ID : M01 RR000046
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000150
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NCRR NIH HHS
ID : UL1 RR025741
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001422
Pays : United States
Organisme : CIHR
ID : MOP-88526
Pays : Canada
Organisme : NIAMS NIH HHS
ID : P30 AR072579
Pays : United States
Organisme : NIAMS NIH HHS
ID : P60 AR064464
Pays : United States
Organisme : NIAMS NIH HHS
ID : P60 AR048098
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR043727
Pays : United States
Organisme : Arthritis Research UK
Pays : United Kingdom
Organisme : NIAMS NIH HHS
ID : K24 AR002138
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2020 American College of Rheumatology.
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