Deep conservation of the enhancer regulatory code in animals.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
06 11 2020
06 11 2020
Historique:
received:
26
04
2019
revised:
29
04
2020
accepted:
30
09
2020
entrez:
6
11
2020
pubmed:
7
11
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
Interactions of transcription factors (TFs) with DNA regulatory sequences, known as enhancers, specify cell identity during animal development. Unlike TFs, the origin and evolution of enhancers has been difficult to trace. We drove zebrafish and mouse developmental transcription using enhancers from an evolutionarily distant marine sponge. Some of these sponge enhancers are located in highly conserved microsyntenic regions, including an
Identifiants
pubmed: 33154111
pii: 370/6517/eaax8137
doi: 10.1126/science.aax8137
pii:
doi:
Substances chimiques
LIM-Homeodomain Proteins
0
Transcription Factors
0
insulin gene enhancer binding protein Isl-1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.