APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).
Aged
Aging
/ genetics
Alleles
Alzheimer Disease
/ ethnology
Apolipoprotein E4
/ genetics
Caribbean Region
/ ethnology
Cognition
Cognitive Dysfunction
/ ethnology
Female
Genotype
Hispanic or Latino
/ genetics
Humans
Male
Middle Aged
Neuropsychological Tests
Prospective Studies
South America
/ ethnology
United States
Alzheimer's disease
Hispanics/Latinos
admixture
ancestry
apolipoprotein E
cognitive decline
genetic epidemiology
mild cognitive impairment
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
pubmed:
7
11
2020
medline:
5
11
2021
entrez:
6
11
2020
Statut:
ppublish
Résumé
Apolipoprotein E (APOE) alleles are associated with cognitive decline, mild cognitive impairment (MCI), and Alzheimer's disease in Whites, but have weaker and inconsistent effects reported in Latinos. We hypothesized that this heterogeneity is due to ancestry-specific genetic effects. We investigated the associations of the APOE alleles with significant cognitive decline and MCI in 4183 Latinos, stratified by six Latino backgrounds, and explored whether the proportion of continental genetic ancestry (European, African, and Amerindian) modifies these associations. APOE ε4 was associated with an increased risk of significant cognitive decline (odds ratio [OR] = 1.15, P-value = 0.03), with the strongest association in Cubans (OR = 1.46, P-value = 0.007). APOE-ε2 was associated with decreased risk of MCI (OR = 0.37, P-value = 0.04) in Puerto Ricans. Amerindian genetic ancestry was found to protect from the risk conferred by APOE ε4 on significant cognitive decline. Results suggest that APOE alleles' effects on cognitive outcomes differ across six Latino backgrounds and are modified by continental genetic ancestry.
Identifiants
pubmed: 33155766
doi: 10.1002/alz.12205
pmc: PMC8016734
mid: NIHMS1677351
doi:
Substances chimiques
Apolipoprotein E4
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
466-474Subventions
Organisme : NINDS NIH HHS
ID : R01 NS017950
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062429
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG052409
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010129
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048642
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG061022
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG048642
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054548
Pays : United States
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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