TCRD and Pharos 2021: mining the human proteome for disease biology.
Animals
Anticonvulsants
/ chemistry
Antiviral Agents
/ chemistry
Biological Products
/ chemistry
Data Mining
/ statistics & numerical data
Databases, Factual
Genome, Human
Host-Pathogen Interactions
/ drug effects
Humans
Internet
Machine Learning
/ statistics & numerical data
Mice
Mice, Knockout
Molecular Targeted Therapy
/ methods
Neurodegenerative Diseases
/ classification
Protein Interaction Mapping
Proteome
/ agonists
Proteomics
/ methods
Small Molecule Libraries
/ chemistry
Software
Virus Diseases
/ classification
Journal
Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011
Informations de publication
Date de publication:
08 01 2021
08 01 2021
Historique:
accepted:
14
10
2020
revised:
09
10
2020
received:
15
09
2020
pubmed:
7
11
2020
medline:
27
1
2021
entrez:
6
11
2020
Statut:
ppublish
Résumé
In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our understanding of poorly characterized proteins that can potentially be modulated using small molecules or biologics. Two resources produced from these efforts are: The Target Central Resource Database (TCRD) (http://juniper.health.unm.edu/tcrd/) and Pharos (https://pharos.nih.gov/), a web interface to browse the TCRD. The ultimate goal of these resources is to highlight and facilitate research into currently understudied proteins, by aggregating a multitude of data sources, and ranking targets based on the amount of data available, and presenting data in machine learning ready format. Since the 2017 release, both TCRD and Pharos have produced two major releases, which have incorporated or expanded an additional 25 data sources. Recently incorporated data types include human and viral-human protein-protein interactions, protein-disease and protein-phenotype associations, and drug-induced gene signatures, among others. These aggregated data have enabled us to generate new visualizations and content sections in Pharos, in order to empower users to find new areas of study in the druggable genome.
Identifiants
pubmed: 33156327
pii: 5958490
doi: 10.1093/nar/gkaa993
pmc: PMC7778974
doi:
Substances chimiques
Anticonvulsants
0
Antiviral Agents
0
Biological Products
0
Proteome
0
Small Molecule Libraries
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
D1334-D1346Subventions
Organisme : NCI NIH HHS
ID : U24 CA224370
Pays : United States
Organisme : NCATS NIH HHS
ID : U24 TR002278
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.
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