A validated measure of rigidity in Parkinson's disease using alternating finger tapping on an engineered keyboard.
Alternating finger tapping
Keyboard
Kinematics
Parkinson's disease
Rigidity
UPDRS
Journal
Parkinsonism & related disorders
ISSN: 1873-5126
Titre abrégé: Parkinsonism Relat Disord
Pays: England
ID NLM: 9513583
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
08
08
2020
revised:
20
10
2020
accepted:
31
10
2020
pubmed:
7
11
2020
medline:
3
11
2021
entrez:
6
11
2020
Statut:
ppublish
Résumé
Reliable and accurate measures of rigidity have remained elusive in remote assessments of Parkinson's disease (PD). This has severely limited the utility of telemedicine in the care and treatment of people with PD. It has also had a large negative impact on the scope of available outcomes, and on the costs, of multicenter clinical trials in PD. The goal of this study was to determine if quantitative measures from an engineered keyboard were sensitive and related to clinical measures of rigidity. Sixteen participants with idiopathic PD, off antiparkinsonian medications, and eleven age-matched control participants performed a 30 second repetitive alternating finger tapping task on an engineered keyboard and were assessed with the Unified Parkinson's Disease Rating Scale - motor (UPDRS-III). The speed of the key release was significantly slower in the PD compared to control cohorts (p < 0.0001). In the PD cohort key release speed correlated with the lateralized upper extremity UPDRS III rigidity score (r = - 0.58, p < 0.0001), but not with the lateralized upper extremity tremor score (r = - 0.14, p = 0.43). This validated measure of rigidity complements our previous validation of temporal metrics of the repetitive alternating finger tapping task with the UPDRS III, bradykinesia and with the ability to quantify tremor, arrhythmicity and freezing episodes, and suggests that 30 seconds of alternating finger tapping on a portable engineered keyboard could transform the treatment of PD with telemedicine and the precision of multicenter clinical trials.
Identifiants
pubmed: 33157435
pii: S1353-8020(20)30848-8
doi: 10.1016/j.parkreldis.2020.10.047
pmc: PMC7770028
mid: NIHMS1645103
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-164Subventions
Organisme : NINDS NIH HHS
ID : UH3 NS107709
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Références
J Clin Mov Disord. 2015 Apr 02;2:8
pubmed: 26788344
J Neurol. 2007 Feb;254(2):202-9
pubmed: 17334954
Mov Disord. 1998 May;13(3):418-21
pubmed: 9613731
Exp Brain Res. 1986;63(3):585-95
pubmed: 3758270
Mov Disord. 2005 Oct;20(10):1286-98
pubmed: 16001401
Brain. 1994 Aug;117 ( Pt 4):877-97
pubmed: 7922472
Mov Disord. 2000 Jan;15(1):36-47
pubmed: 10634240
Mov Disord. 2009 Mar 15;24(4):551-6
pubmed: 19086085
Mov Disord. 2008 Nov 15;23(15):2129-70
pubmed: 19025984
Exp Brain Res. 2012 Jun;219(4):499-506
pubmed: 22580572
Mov Disord. 2008 Jul 15;23(9):1262-8
pubmed: 18464283
J Neurosci Methods. 2019 Apr 1;317:113-120
pubmed: 30776378