Epidemiological hypothesis testing using a phylogeographic and phylodynamic framework.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
06 11 2020
Historique:
received: 11 03 2020
accepted: 30 09 2020
entrez: 7 11 2020
pubmed: 8 11 2020
medline: 15 12 2020
Statut: epublish

Résumé

Computational analyses of pathogen genomes are increasingly used to unravel the dispersal history and transmission dynamics of epidemics. Here, we show how to go beyond historical reconstructions and use spatially-explicit phylogeographic and phylodynamic approaches to formally test epidemiological hypotheses. We illustrate our approach by focusing on the West Nile virus (WNV) spread in North America that has substantially impacted public, veterinary, and wildlife health. We apply an analytical workflow to a comprehensive WNV genome collection to test the impact of environmental factors on the dispersal of viral lineages and on viral population genetic diversity through time. We find that WNV lineages tend to disperse faster in areas with higher temperatures and we identify temporal variation in temperature as a main predictor of viral genetic diversity through time. By contrasting inference with simulation, we find no evidence for viral lineages to preferentially circulate within the same migratory bird flyway, suggesting a substantial role for non-migratory birds or mosquito dispersal along the longitudinal gradient.

Identifiants

pubmed: 33159066
doi: 10.1038/s41467-020-19122-z
pii: 10.1038/s41467-020-19122-z
pmc: PMC7648063
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

5620

Subventions

Organisme : NIAID NIH HHS
ID : U19 AI135995
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI107034
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : Wellcome Trust
ID : 206298/Z/17/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : U01 AI151812
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI149004
Pays : United States

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Auteurs

Simon Dellicour (S)

Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, CP160/12, 50 Avenue FD Roosevelt, 1050, Bruxelles, Belgium. simon.dellicour@ulb.ac.be.
Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium. simon.dellicour@ulb.ac.be.

Sebastian Lequime (S)

Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Bram Vrancken (B)

Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Mandev S Gill (MS)

Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Paul Bastide (P)

Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Karthik Gangavarapu (K)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.

Nathaniel L Matteson (NL)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.

Yi Tan (Y)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Infectious Diseases Group, J. Craig Venter Institute, Rockville, MD, USA.

Louis du Plessis (L)

Department of Zoology, University of Oxford, Oxford, UK.

Alexander A Fisher (AA)

Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Martha I Nelson (MI)

Fogarty International Center, National Institutes of Health, Bethesda, MD, 20894, USA.

Marius Gilbert (M)

Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, CP160/12, 50 Avenue FD Roosevelt, 1050, Bruxelles, Belgium.

Marc A Suchard (MA)

Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Kristian G Andersen (KG)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Scripps Research Translational Institute, La Jolla, CA, 92037, USA.

Nathan D Grubaugh (ND)

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.

Oliver G Pybus (OG)

Department of Zoology, University of Oxford, Oxford, UK.

Philippe Lemey (P)

Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

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