Anti-NMDAR encephalitis may develop concurrently with anti-MOG antibody-associated bilateral medial frontal cerebral cortical encephalitis and relapse with elevated CSF IL-6 and CXCL13.
Anti-N-methyl-D-aspartate receptor encephalitis
CXCL13
IL-6
Myelin oligodendrocyte glycoprotein
Relapse
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
07
10
2020
accepted:
31
10
2020
pubmed:
8
11
2020
medline:
15
5
2021
entrez:
7
11
2020
Statut:
ppublish
Résumé
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis may develop concurrently with or separate from episodes of demyelinating disorders. Previously, we reported a patient with relapsing anti-NMDAR encephalitis who had presented with bilateral medial frontal cerebral cortical lesions at onset. Recently, we assessed CSF anti-myelin oligodendrocyte glycoprotein (MOG) antibody for the first time in this case and found that the patient had been double positive for anti-NMDAR and anti-MOG antibodies from onset. The two antibody titres, CSF cells, IL-6 and CXCL13 were all elevated at onset. Anti-NMDAR encephalitis may develop concurrently with anti-MOG antibody-associated cortical encephalitis and relapse with elevated levels of CSF cytokines.
Identifiants
pubmed: 33160141
pii: S2211-0348(20)30685-4
doi: 10.1016/j.msard.2020.102611
pii:
doi:
Substances chimiques
Autoantibodies
0
CXCL13 protein, human
0
Chemokine CXCL13
0
IL6 protein, human
0
Interleukin-6
0
Myelin-Oligodendrocyte Glycoprotein
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
102611Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.