[Accountability of anti-cholinergic drugs in increase of psychotic episodes: A case of tropatepine overdose].
Imputabilité des traitements anticholinergiques dans l’exacerbation d’épisodes psychotiques : à propos d’un cas de surdosage en tropatépine.
Anticholinergic
Anticholinergique
Drug poisoning
Iatrogenic medications
Iatrogénie médicamenteuse
Intoxication médicamenteuse
Psychotic episode
Tropatepine
Tropatépine
Épisode psychotique
Journal
La Revue de medecine interne
ISSN: 1768-3122
Titre abrégé: Rev Med Interne
Pays: France
ID NLM: 8101383
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
17
01
2020
revised:
31
07
2020
accepted:
29
08
2020
pubmed:
11
11
2020
medline:
25
11
2021
entrez:
10
11
2020
Statut:
ppublish
Résumé
Corrective treatments for some neurological side effects due to antipsychotic treatments can induce anticholinergic adverse effects. However, the risk of triggering or increasing psychotic symptoms induced by these drugs is unknown with only one case-report concerning the tropatepine. In addition, recommendations for the use of these drugs remain imprecise regarding the management of this type of adverse effect. We report the case of a psychotic episode in an 18-year-old patient potentially acutised after an auto-intoxication with tropatepine. At high doses, anticholinergic treatments, including tropatepine, might increase psychotic episodes. In addition, the available epidemiological data reveal an inappropriate and excessive prescription of these drugs. Their use and risks should be better known and need an update of the available recommendations.
Identifiants
pubmed: 33168356
pii: S0248-8663(20)30364-7
doi: 10.1016/j.revmed.2020.08.015
pii:
doi:
Substances chimiques
Cholinergic Antagonists
0
Dibenzothiepins
0
Pharmaceutical Preparations
0
tropatepine
C27HY5RFU5
Types de publication
Case Reports
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
127-130Informations de copyright
Copyright © 2020 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.