Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 11 2020
09 11 2020
Historique:
received:
02
01
2020
accepted:
10
10
2020
entrez:
10
11
2020
pubmed:
11
11
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Human endogenous retroviruses (HERV) form a substantial part of the human genome, but mostly remain transcriptionally silent under strict epigenetic regulation, yet can potentially be reactivated by malignant transformation or epigenetic therapies. Here, we evaluate the potential for T cell recognition of HERV elements in myeloid malignancies by mapping transcribed HERV genes and generating a library of 1169 potential antigenic HERV-derived peptides predicted for presentation by 4 HLA class I molecules. Using DNA barcode-labeled MHC-I multimers, we find CD8
Identifiants
pubmed: 33168830
doi: 10.1038/s41467-020-19464-8
pii: 10.1038/s41467-020-19464-8
pmc: PMC7653045
doi:
Substances chimiques
Epitopes, T-Lymphocyte
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5660Références
Immunogenetics. 2009 Jan;61(1):1-13
pubmed: 19002680
Nat Rev Genet. 2011 Aug 18;12(9):615-27
pubmed: 21850042
Cell Rep. 2017 Jul 18;20(3):572-585
pubmed: 28723562
Genome Res. 2011 Jul;21(7):1150-9
pubmed: 21596820
Eur J Immunol. 2013 Apr;43(4):1109-20
pubmed: 23280567
Nat Med. 2006 Feb;12(2):246-51
pubmed: 16462803
Oncoimmunology. 2012 Nov 1;1(8):1305-1312
pubmed: 23243594
Clin Cancer Res. 2001 Jun;7(6):1553-60
pubmed: 11410490
N Engl J Med. 2017 Dec 21;377(25):2500-2501
pubmed: 29262275
Ann Oncol. 2018 Apr 1;29(4):1030-1036
pubmed: 29360924
Cell Rep. 2014 Dec 24;9(6):2084-97
pubmed: 25533346
Trends Immunol. 2017 Aug;38(8):542-557
pubmed: 28579323
Nat Protoc. 2006;1(3):1120-32
pubmed: 17406393
Methods Mol Biol. 2009;524:383-405
pubmed: 19377960
Cytometry A. 2015 Oct;87(10):967-75
pubmed: 26033882
J Clin Invest. 2018 Nov 1;128(11):4804-4820
pubmed: 30137025
Cell. 2015 Jan 15;160(1-2):48-61
pubmed: 25594174
J Virol. 2005 Jan;79(2):876-83
pubmed: 15613316
Oncotarget. 2015 Nov 24;6(37):40095-111
pubmed: 26517682
Oncotarget. 2015 Apr 20;6(11):9612-26
pubmed: 25823822
Cancer Res. 2005 May 15;65(10):4172-80
pubmed: 15899808
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3825-30
pubmed: 18308940
Blood. 2013 Apr 11;121(15):3005-15
pubmed: 23372164
J Clin Invest. 2008 Mar;118(3):1099-109
pubmed: 18292810
Leukemia. 2014 Jun;28(6):1280-8
pubmed: 24270737
Cancer Cell. 2014 Jun 16;25(6):794-808
pubmed: 24835589
Int J Cancer. 2007 Jan 1;120(1):81-90
pubmed: 17013901
Blood. 2012 Sep 20;120(12):2454-65
pubmed: 22740453
Nat Rev Microbiol. 2012 May 08;10(6):395-406
pubmed: 22565131
Nat Genet. 2017 Jul;49(7):1052-1060
pubmed: 28604729
JCI Insight. 2018 Aug 23;3(16):
pubmed: 30135306
Nat Rev Genet. 2012 Mar 16;13(4):283-96
pubmed: 22421730
Cancer Res. 2012 Apr 1;72(7):1642-50
pubmed: 22311675
Clin Epigenetics. 2016 Jun 21;8:71
pubmed: 27330573
Science. 2016 Mar 25;351(6280):1463-9
pubmed: 26940869
Cancer Immunol Immunother. 2012 Jul;61(7):1093-100
pubmed: 22187063
Trends Cell Biol. 2019 Jan;29(1):31-43
pubmed: 30153961
Cancer Res. 2020 Jun 15;80(12):2441-2450
pubmed: 32245794
Cell Commun Signal. 2017 Mar 31;15(1):13
pubmed: 28359286
Nature. 2017 Aug 24;548(7668):471-475
pubmed: 28813415
Blood. 2006 Jul 15;108(2):419-25
pubmed: 16609072
Cell. 2015 Aug 27;162(5):961-73
pubmed: 26317465
Nucleic Acids Res. 2009 Jan;37(Database issue):D816-9
pubmed: 18838390
AIDS Res Hum Retroviruses. 2006 Jan;22(1):52-6
pubmed: 16438646
Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10238-44
pubmed: 27573823
Cell Rep. 2018 Apr 10;23(2):512-521
pubmed: 29642008
Science. 2015 Apr 3;348(6230):69-74
pubmed: 25838375
Nat Rev Cancer. 2019 Mar;19(3):151-161
pubmed: 30723290
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6642-E6651
pubmed: 28739914
Cancer J. 2017 Sep/Oct;23(5):277-285
pubmed: 28926428
Cancer Res. 2008 Jul 15;68(14):5869-77
pubmed: 18632641
Ann Oncol. 2018 Nov 1;29(11):2183-2191
pubmed: 30239576
Sci Transl Med. 2018 Dec 5;10(470):
pubmed: 30518613
Blood. 2009 Jul 30;114(5):937-51
pubmed: 19357394
Epigenetics. 2006 Jul-Sep;1(3):116-20
pubmed: 17786175
Br J Haematol. 2011 Jun;153(5):568-81
pubmed: 21488861
Curr Opin Virol. 2013 Dec;3(6):646-56
pubmed: 24004725
Mob DNA. 2011 May 04;2(1):7
pubmed: 21542922
APMIS. 1998 Jan;106(1):216-20
pubmed: 9524581
Nat Biotechnol. 2016 Oct;34(10):1037-1045
pubmed: 27571370
Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732):
pubmed: 28893944
Leukemia. 2018 May;32(5):1094-1105
pubmed: 29487386
Cancer Res. 2002 Oct 1;62(19):5510-6
pubmed: 12359761
Cancer. 2003 Jul 1;98(1):187-97
pubmed: 12833471
Cancer Res. 2016 Apr 15;76(8):2177-85
pubmed: 26862115
Cell. 2015 Aug 27;162(5):974-86
pubmed: 26317466
PLoS One. 2013 Nov 13;8(11):e78474
pubmed: 24236019
Leukemia. 2015 Aug;29(8):1798
pubmed: 26242354