Vascular protective effect of aspirin and rivaroxaban upon endothelial denudation of the mouse carotid artery.
Animals
Arteries
/ drug effects
Aspirin
/ pharmacology
Blood Platelets
/ metabolism
Carotid Arteries
/ drug effects
Carotid Artery Diseases
/ drug therapy
Carotid Intima-Media Thickness
Factor Xa Inhibitors
/ pharmacology
Leukocytes
/ metabolism
Male
Mice
Mice, Inbred C57BL
Microscopy, Electron, Scanning
Platelet Aggregation Inhibitors
/ therapeutic use
Rivaroxaban
/ pharmacology
Thrombosis
/ drug therapy
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 11 2020
09 11 2020
Historique:
received:
24
06
2020
accepted:
27
10
2020
entrez:
10
11
2020
pubmed:
11
11
2020
medline:
1
5
2021
Statut:
epublish
Résumé
While in recent trials the dual pathway inhibition with aspirin plus rivaroxaban has shown to be efficacious in patients with atherosclerotic cardiovascular disease, little is known about the effects of this combination treatment on thrombus formation and vascular remodelling upon vascular damage. The aim of this study was to examine the effects of aspirin and/or rivaroxaban on injury-induced murine arterial thrombus formation in vivo and in vitro, vessel-wall remodelling, and platelet-leukocyte aggregates. Temporary ligation of the carotid artery of C57BL/6 mice, fed a western type diet, led to endothelial denudation and sub-occlusive thrombus formation. At the site of ligation, the vessel wall stiffened and the intima-media thickened. Aspirin treatment antagonized vascular stiffening and rivaroxaban treatment led to a positive trend towards reduced stiffening. Local intima-media thickening was antagonized by both aspirin or rivaroxaban treatment. Platelet-leukocyte aggregates and the number of platelets per leukocyte were reduced in aspirin and/or rivaroxaban treatment groups. Furthermore, rivaroxaban restricted thrombus growth and height in vitro. In sum, this study shows vascular protective effects of aspirin and rivaroxaban, upon vascular injury of the mouse artery.
Identifiants
pubmed: 33168914
doi: 10.1038/s41598-020-76377-8
pii: 10.1038/s41598-020-76377-8
pmc: PMC7653917
doi:
Substances chimiques
Factor Xa Inhibitors
0
Platelet Aggregation Inhibitors
0
Rivaroxaban
9NDF7JZ4M3
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19360Références
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