The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms.
intein
protease
protein engineering
protein evolution
protein-splicing mechanism
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Nov 2020
07 Nov 2020
Historique:
received:
25
09
2020
revised:
01
11
2020
accepted:
05
11
2020
entrez:
11
11
2020
pubmed:
12
11
2020
medline:
2
3
2021
Statut:
epublish
Résumé
Protein splicing catalyzed by inteins utilizes many different combinations of amino-acid types at active sites. Inteins have been classified into three classes based on their characteristic sequences. We investigated the structural basis of the protein splicing mechanism of class 3 inteins by determining crystal structures of variants of a class 3 intein from
Identifiants
pubmed: 33171880
pii: ijms21218367
doi: 10.3390/ijms21218367
pmc: PMC7664689
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Hedgehog Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Academy of Finland
ID : 277335,315596
Organisme : Novo Nordisk Fonden
ID : NNF17OC0025402,NNF17OC0027550
Organisme : NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : Biocenter Finland
ID : N.A.
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