Tetrapodal Anion Transporters.
anion transport
anion-selective transport
lipid bilayer
supramolecular chemistry
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Nov 2020
06 Nov 2020
Historique:
received:
02
10
2020
revised:
30
10
2020
accepted:
03
11
2020
entrez:
11
11
2020
pubmed:
12
11
2020
medline:
29
4
2021
Statut:
epublish
Résumé
Synthetic anion transporters that facilitate chloride transport are promising candidates for channelopathy treatments. However, most anion transporters exhibit an undesired side effect of facilitating proton transport via interacting with fatty acids present in the membrane. To address the limitation, we here report the use of a new tetrapodal scaffold to maximize the selective interaction with spherical chloride over binding the carboxylate headgroup of fatty acids. One of the new transporters demonstrated a high selectivity for chloride uniport over fatty acid-induced proton transport while being >10 times more active in chloride uniport than strapped calixpyrroles that were previously the only class of compounds known to possess similar selectivity properties.
Identifiants
pubmed: 33172141
pii: molecules25215179
doi: 10.3390/molecules25215179
pmc: PMC7664440
pii:
doi:
Substances chimiques
8-hydroxy-1,3,6-pyrenetrisulfonic acid
0
Anion Transport Proteins
0
Anions
0
Chlorides
0
Fatty Acids
0
Lipid Bilayers
0
Nitrates
0
Pyrenes
0
Sulfonic Acids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Australian Research Council
ID : DP180100612
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