ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota.
autophagy
colitis
esrra
gut
inflammation
inflammatory bowel diseases
microbiome
transcription factor EB
ulcerative colitis
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
pubmed:
12
11
2020
medline:
8
4
2022
entrez:
11
11
2020
Statut:
ppublish
Résumé
The orphan nuclear receptor ESRRA (estrogen related receptor alpha) is critical in mitochondrial biogenesis and macroautophagy/autophagy function; however, the roles of ESRRA in intestinal function remain uncharacterized. Herein we identified that ESRRA acts as a key regulator of intestinal homeostasis by amelioration of colonic inflammation through activation of autophagic flux and control of host gut microbiota.
Identifiants
pubmed: 33172329
doi: 10.1080/15548627.2020.1847460
pmc: PMC8525935
doi:
Substances chimiques
Estrogens
0
Dextran Sulfate
9042-14-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2856-2875Références
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