The Transcription Factor SomA Synchronously Regulates Biofilm Formation and Cell Wall Homeostasis in
Aspergillus fumigatus
biofilm
cell wall
fungal pathogen
polysaccharides
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
10 11 2020
10 11 2020
Historique:
entrez:
11
11
2020
pubmed:
12
11
2020
medline:
4
9
2021
Statut:
epublish
Résumé
Polysaccharides are key components of both the fungal cell wall and biofilm matrix. Despite having distinct assembly and regulation pathways, matrix exopolysaccharide and cell wall polysaccharides share common substrates and intermediates in their biosynthetic pathways. It is not clear, however, if the biosynthetic pathways governing the production of these polysaccharides are cooperatively regulated. Here, we demonstrate that cell wall stress promotes production of the exopolysaccharide galactosaminogalactan (GAG)-depend biofilm formation in the major fungal pathogen of humans
Identifiants
pubmed: 33173002
pii: mBio.02329-20
doi: 10.1128/mBio.02329-20
pmc: PMC7667024
pii:
doi:
Substances chimiques
Fungal Proteins
0
Polysaccharides
0
Transcription Factors
0
galactosaminogalactan
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : 81361
Pays : Canada
Organisme : CIHR
ID : 123306
Pays : Canada
Organisme : CIHR
ID : FDN-159902
Pays : Canada
Informations de copyright
Copyright © 2020 Chen et al.
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