Higher Increase in Plasma DHA in Females Compared to Males Following EPA Supplementation May Be Influenced by a Polymorphism in ELOVL2: An Exploratory Study.
Docosahexaenoic acid
Eicosapentaenoic acid
Elongation of very long-chain 2 (ELOVL2)
Genetics
Nutrition
Sex
Journal
Lipids
ISSN: 1558-9307
Titre abrégé: Lipids
Pays: United States
ID NLM: 0060450
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
revised:
26
10
2020
received:
24
07
2020
accepted:
28
10
2020
pubmed:
12
11
2020
medline:
27
10
2021
entrez:
11
11
2020
Statut:
ppublish
Résumé
Young adult females have higher blood docosahexaenoic acid (DHA), 22:6n-3 levels than males, and this is believed to be due to higher DHA synthesis rates, although DHA may also accumulate due to a longer half-life or a combination of both. However, sex differences in blood fatty acid responses to eicosapentaenoic acid (EPA), 20:5n-3 or DHA supplementation have not been fully investigated. In this exploratory analysis, females and males (n = 14-15 per group) were supplemented with 3 g/day EPA, 3 g/day DHA, or olive oil control for 12 weeks. Plasma was analyzed for sex effects at baseline and changes following 12 weeks' supplementation for fatty acid levels and carbon-13 signature (δ
Substances chimiques
ELOVL2 protein, human
0
Docosahexaenoic Acids
25167-62-8
eicosapentaenoic acid ethyl ester
6GC8A4PAYH
Eicosapentaenoic Acid
AAN7QOV9EA
Fatty Acid Elongases
EC 2.3.1.-
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
211-228Informations de copyright
© 2020 AOCS.
Références
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